Unique ID issued by UMIN | UMIN000025357 |
---|---|
Receipt number | R000029190 |
Scientific Title | Risk stratification for sudden cardiac death in patients with mitral valve prolapse, based on cardiac imaging |
Date of disclosure of the study information | 2020/07/31 |
Last modified on | 2018/01/02 17:37:47 |
Risk stratification for sudden cardiac death in patients with mitral valve prolapse, based on cardiac imaging
Risk stratification for sudden cardiac death in mitral valve prolapse
Risk stratification for sudden cardiac death in patients with mitral valve prolapse, based on cardiac imaging
Risk stratification for sudden cardiac death in mitral valve prolapse
Europe |
Mitral valve prolapse
Cardiology |
Others
NO
Sudden cardiac death is an important health issue, still affection 1 on 1000 persons per year. Mitral valve prolapse has since long been associated with sudden cardiac death in young people. The pathophysiological link between the presence of mitral valve prolapse and the occurrence of sudden cardiac death is not yet fully understood. Furthermore, guidelines for the assessment of the arrhythmic risk in patients with mitral valve prolapse are lacking.
In this study, the arrhythmic profile of patients with mitral valve prolapse will be assessed based on repeated Holter monitoring recordings. Transthoracic echocardiography and cardiac magnetic resonance will be performed in order to detect subtle structural and mechanical changes. Blood samples will be collected to look for potential biomarkers. Electrophysiological data and respectively imaging features and biological data will be correlated. In this way, new predictors for the risk of severe ventricular arrhythmias in patients with mitral valve prolapse can be identified. This will also allow to further elucidate the pathophysiological link between mitral valve prolapse and the occurence of severe arrhythmias.
Others
Diagnostic
Exploratory
Explanatory
Not applicable
(Aborted) sudden cardiac death or severe ventricular arrhythmias. After 2 years.
Premature ventricular complexes
Interventional
Single arm
Non-randomized
Open -no one is blinded
Uncontrolled
1
Diagnosis
Other |
Baseline cardiac magnetic resonance and echocardiography. ECG and Holter monitoring every 6 months.
18 | years-old | <= |
100 | years-old | > |
Male and Female
Diagnosis of mitral valve prolapse or Barlow's disease on echocardiography
Ability to give informed consent
Severe valvular disease or heart disease from a different origine
Severe renal failure
Life expectancy of less than one year
Inability to give informed consent
120
1st name | |
Middle name | |
Last name | Esther Scheirlynck |
Universitair ziekenhuis Brussel
Cardiology department
Laarbeeklaan 101, 1090 Jette
00324776009
escheirl@vub.ac.be
1st name | |
Middle name | |
Last name | Esther Scheirlynck |
Universitair ziekenhuis Brussel
Cardiology department
Laarbeeklaan 101, 1090 Jette
00324776009
escheirl@vub.ac.be
Cardiology department UZ Brussel, under supervision of Bernard Cosyns
Cardiology department UZ Brussel, under supervision of Bernard Cosyns
Self funding
NO
University hospital (Brussels)
2020 | Year | 07 | Month | 31 | Day |
Unpublished
Preinitiation
2016 | Year | 12 | Month | 31 | Day |
2017 | Year | 01 | Month | 02 | Day |
2017 | Year | 12 | Month | 22 | Day |
2016 | Year | 12 | Month | 21 | Day |
2018 | Year | 01 | Month | 02 | Day |
Value
https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000029190