Unique ID issued by UMIN | UMIN000025331 |
---|---|
Receipt number | R000029140 |
Scientific Title | Research on the effect of a proton pump inhibitor on the oral and intestinal microbiota and salivary protein and metabolites. |
Date of disclosure of the study information | 2016/12/20 |
Last modified on | 2016/12/20 08:21:42 |
Research on the effect of a proton pump inhibitor on the oral and intestinal microbiota and salivary protein and metabolites.
Influence of PPI on oral microbiota
Research on the effect of a proton pump inhibitor on the oral and intestinal microbiota and salivary protein and metabolites.
Influence of PPI on oral microbiota
Japan |
healthy volunteer
Gastroenterology |
Others
NO
The aim of the present study was to explore the influence of PPI usage on the oral and gut microbiota with healthy volunteers.
Bio-equivalence
Ten adult healthy volunteers with no medications donated the fecal, saliva and periodontal pocket fluid samples before and after administration of esomeprazole 20mg once daily for 4 weeks. We then investigate the effect of PPIs on the bacterial communities using 16S rRNA gene sequencing method.
Others,meta-analysis etc
20 | years-old | <= |
80 | years-old | > |
Male and Female
1) over 20 year old
2) Informed consent about this research has been obtained with participants in writing form.
1) daily usage of steroids, immunosuppresive and anticancer drugs
2) 20 or fewer teeth
3) using antibiotics during use or within 1 month
4) During pregnancy, lactating, a woman who may be pregnant
5) history of allergy to esomeprazole
6) A case of a history of resection of the gastrointestinal tract except for appendectomy
7) the research director judged inappropriate as the subject of this research
24
1st name | |
Middle name | |
Last name | Tsuyoshi Mishiro |
Shimane university school of medicine
Division of gastroenterology
89-1 Enya-cho, Izumo, Shimane, Japan
0853-20-2190
tmishiro@med.shimane-u.ac.jp
1st name | |
Middle name | |
Last name | Tsuyoshi Mishiro |
Shimane university school of medicine
Division of gastroenterology
89-1 Enya-cho, Izumo, Shimane, Japan
0853-20-2190
tmishiro@med.shimane-u.ac.jp
Shimane university
self funding
Self funding
NO
2016 | Year | 12 | Month | 20 | Day |
Unpublished
2015 | Year | 12 | Month | 02 | Day |
2016 | Year | 12 | Month | 20 | Day |
Ten adult healthy volunteers with no medications donated the fecal, saliva and periodontal pocket fluid samples before and after administration of esomeprazole 20mg once daily for 4 weeks. We then investigate the effect of PPIs on the bacterial communities using 16S rRNA gene sequencing method.
2016 | Year | 12 | Month | 20 | Day |
2016 | Year | 12 | Month | 20 | Day |
Value
https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000029140