Unique ID issued by UMIN | UMIN000024724 |
---|---|
Receipt number | R000028445 |
Scientific Title | The study to elucidate the mechanism of pathogenesis of atrial fibrillation targeting mitochondria in atrial myocardium |
Date of disclosure of the study information | 2016/11/08 |
Last modified on | 2025/05/12 20:27:40 |
The study to elucidate the mechanism of pathogenesis of atrial fibrillation targeting mitochondria in atrial myocardium
AFMITO Study
The study to elucidate the mechanism of pathogenesis of atrial fibrillation targeting mitochondria in atrial myocardium
AFMITO Study
Japan |
Atrial fibrillation
Cardiology |
Others
NO
To test the hypothesis that impaired mitochondrial oxidative phosphorylation capacity and mitochondrial oxidative stress in atrial myocardium might contribute to pathogenesis and development of atrial fibrillation
Others
To elucidate the mechanism of pathogenesis and development of atrial fibrillation
Mitochondrial oxidative phosphorylation capacity and mitochondrial reactive oxygen species (ROS) release in atrial myocardium
1.Systemic oxidative stress
2.Systemic inflammation
3.Intramyocellular lipid in atrial myocardium
4.Mitochondrial density in atrial myocardium
5.Gene expression and protein content in atrial myocardium
Observational
20 | years-old | <= |
Not applicable |
Male and Female
Patients with cardiovascular disease who will undergo incision of right atrium in open-heart surgery
1. Patients who cannot give written informed consent
2. Patients who are considered inappropriate for the study by the principal investigator
68
1st name | Takashi |
Middle name | |
Last name | Yokota |
Faculty of Medicine and Graduate School of Medicine, Hokkaido University
Department of Cardiovascular Medicine
060-8638
Kita-15 Nishi-7, Kita-Ku, Sapporo, Japan
011-706-6973
t-yokota@med.hokudai.ac.jp
1st name | Takashi |
Middle name | |
Last name | Yokota |
Faculty of Medicine and Graduate School of Medicine, Hokkaido University
Department of Cardiovascular Medicine
060-8638
Kita-15 Nishi-7, Kita-Ku, Sapporo, Japan
011-706-6973
t-yokota@med.hokudai.ac.jp
Hokkaido University
Japan Science and Technology Agency
Japanese Governmental office
Teine Keijinkai Hospital
Institutional Review Board of Hokkaido University Hospital
Kita-14 Nishi-5, Kita-Ku, Sapporo 060-8648, Japan
011-706-7636
crjimu@huhp.hokudai.ac.jp
NO
2016 | Year | 11 | Month | 08 | Day |
Unpublished
Completed
2016 | Year | 08 | Month | 05 | Day |
2016 | Year | 08 | Month | 05 | Day |
2016 | Year | 11 | Month | 08 | Day |
2022 | Year | 03 | Month | 31 | Day |
1. Observational study
2. Case-control study
2016 | Year | 11 | Month | 05 | Day |
2025 | Year | 05 | Month | 12 | Day |
Value
https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000028445