Unique ID issued by UMIN | UMIN000024363 |
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Receipt number | R000028046 |
Scientific Title | A Comparison of Analgesic Effect between Loxoprofen and Celecoxib and the Frequency of the Hemorrhage Following Tonsillectomy |
Date of disclosure of the study information | 2016/12/01 |
Last modified on | 2017/04/17 15:03:31 |
A Comparison of Analgesic Effect between Loxoprofen and Celecoxib
and the Frequency of the Hemorrhage Following Tonsillectomy
A Comparison of Analgesic Effect between Loxoprofen and Celecoxib
and the Frequency of the Hemorrhage Following Tonsillectomy
A Comparison of Analgesic Effect between Loxoprofen and Celecoxib
and the Frequency of the Hemorrhage Following Tonsillectomy
A Comparison of Analgesic Effect between Loxoprofen and Celecoxib
and the Frequency of the Hemorrhage Following Tonsillectomy
Japan |
chronic tonsillitis,peritonsillar abscess,sleep apnea syndrome
Oto-rhino-laryngology | Adult |
Others
NO
For a pain-killer to give after palatine tonsil enucleation, conventional NSAIDs is often chosen. However, because NSAIDs inhibits both of COX-1 and COX-2 nonselectively, I control the platelet aggregation action that is physiological action of COX-1 at the same time, and the possibility that it becomes the factor of the bleeding after art has it pointed out. In contrast, it is said that there are few side effects such as the bleeding tendency because NSAIDs having selective COX-2 inhibition does not control platelet aggregation action. Therefore I examine painkilling effects enough again whether you reduce frequency of the bleeding after art more when it chooses conventional NSAIDs (loxoprofen) to choose selective COX-2 inhibitor (celecoxib) as a pain-killer this time whether you are provided safely.
Safety,Efficacy
On a patient background, the total dosage days of the pain-killer, the self-evaluation (I include VAS scale) for the painkilling effect, a ratio (rescue dosage rate), the days of the case receiving the rescue, a last dosage day, I did it with a side effect after presence of the bleeding and degree, art after a side effect, a hospitalized total eating rate, art at time of the bleeding.
Interventional
Parallel
Randomized
Cluster
Open -no one is blinded
Active
2
Treatment
Medicine |
Only as for the first time, I gave 200 mg of once after dinner after the second at 400 mg with celecoxib twice a day for the celecoxib group in morning after the next day five hours after an operation.
I gave 60 mg of loxoprofen after every meal with 60 mg of once after the second three times a day for the loxoprofen group five hours after an operation only in the first time.
15 | years-old | <= |
100 | years-old | >= |
Male and Female
Patients such as tonsillitis chronic in 15 years old or more that enforced both sides palatine tonsil enucleation on January 1, 2017 by December 31, 2017, almond peritonsillar abscess, sleep apnea syndrome.
The Patient of allergy to celecoxib and bronchial asthma is excluded
30
1st name | |
Middle name | |
Last name | Makoto Sugiura |
Tosei General Hospital
Otolaryngology
160, Nishioiwakecho, Seto-shi, Aichi
0561825101
masahirof@tosei.or.jp
1st name | |
Middle name | |
Last name | Masahiro Fukushima |
Tosei General Hospital
Otolaryngology
160, Nishioiwakecho, Seto-shi, Aichi
0561825101
masahirof@tosei.or.jp
Tosei General Hospital
nothing
Other
NO
2016 | Year | 12 | Month | 01 | Day |
Unpublished
Preinitiation
2016 | Year | 12 | Month | 01 | Day |
2016 | Year | 12 | Month | 01 | Day |
2016 | Year | 10 | Month | 11 | Day |
2017 | Year | 04 | Month | 17 | Day |
Value
https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000028046
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