UMIN-CTR Clinical Trial
| Unique ID issued by UMIN | UMIN000023816 |
|---|---|
| Receipt number | R000027436 |
| Scientific Title | effect of increase arterial stiffness by resistance training on cerebral hemodynamic |
| Date of disclosure of the study information | 2016/08/29 |
| Last modified on | 2022/07/02 21:20:24 |
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Basic information
Public title
effect of increase arterial stiffness by resistance training on cerebral hemodynamic
Acronym
effect of resistance training on cerebral hemodynamic
Scientific Title
effect of increase arterial stiffness by resistance training on cerebral hemodynamic
Scientific Title:Acronym
effect of resistance training on cerebral hemodynamic
Region
| Japan |
Condition
Condition
healthy adult men
Classification by specialty
| Adult |
Classification by malignancy
Others
Genomic information
NO
Objectives
Narrative objectives1
The purpose of this study was to evaluate whether increase arterial stiffness by resistance training on cerebral hemodynamic.
Also, The purpose of this study was to examine the effect of increased central arterial stiffness and decreased arterial compliance by RT on CBF pulsatility. To investigate this purpose, we designed a cross-sectional study in which central arterial stiffness and compliance, and CBF pulsatility in resistance-trained men were compared with those in age-matched non-resistance-trained subjects.
Basic objectives2
Safety,Efficacy
Basic objectives -Others
Trial characteristics_1
Trial characteristics_2
Developmental phase
Assessment
Primary outcomes
Effect of increase arterial stiffness by resistance training on cerebral hemodynamic.
Key secondary outcomes
Base
Study type
Interventional
Study design
Basic design
Parallel
Randomization
Non-randomized
Randomization unit
Blinding
Open -no one is blinded
Control
No treatment
Stratification
Dynamic allocation
Institution consideration
Blocking
Concealment
Intervention
No. of arms
2
Purpose of intervention
Educational,Counseling,Training
Type of intervention
| Other |
Interventions/Control_1
Exercise intensity was 75-80% of Repetition Mmaximal and exercise duration was 30 minutes.
Interventions/Control_2
To keep normal life
Interventions/Control_3
Interventions/Control_4
Interventions/Control_5
Interventions/Control_6
Interventions/Control_7
Interventions/Control_8
Interventions/Control_9
Interventions/Control_10
Eligibility
Age-lower limit
| 20 | years-old | <= |
Age-upper limit
| 30 | years-old | >= |
Gender
Male
Key inclusion criteria
healthy adult over 20 years old.
The resistance-trained men had been performing vigorous RT for >2 years, >5 days/week.
Key exclusion criteria
subjects who are stopped exercise by doctor, have diabetes, have cardiovascular disease, orthopedic pain, smoking habit.
None of the subjects in the sedentary group regularly engaged in RT. All the subjects were normotensive (<140/90 mmHg), and none of them ever used medications such as anabolic steroids.
Target sample size
60
Research contact person
Name of lead principal investigator
| 1st name | Isao |
| Middle name | |
| Last name | Muraoka |
Organization
Waseda University
Division name
Faculty of Sport Sciences
Zip code
359-1192
Address
2-579-15 Mikajima, Tokorozawa, Saitama 359-1192
TEL
04-2947-7128
imuraoka@waseda.jp
Public contact
Name of contact person
| 1st name | Nobuhiro |
| Middle name | |
| Last name | Nakamura |
Organization
Waseda University
Division name
Graduate School of Sport Sciences
Zip code
359-1192
Address
2-579-15 Mikajima, Tokorozawa, Saitama 359-1192
TEL
04-2947-7128
Homepage URL
nobu0902@toki.waseda.jp
Sponsor or person
Institute
Waseda University
Institute
Department
Personal name
Funding Source
Organization
A Waseda University Grant
Organization
Division
Category of Funding Organization
Other
Nationality of Funding Organization
Other related organizations
Co-sponsor
Name of secondary funder(s)
IRB Contact (For public release)
Organization
Waseda University
Address
1-104 Totsukamachi, Shinjuku-ku, Tokyo
Tel
0352721639
rinri@list.waseda.jp
Secondary IDs
Secondary IDs
NO
Study ID_1
Org. issuing International ID_1
Study ID_2
Org. issuing International ID_2
IND to MHLW
Institutions
Institutions
Other administrative information
Date of disclosure of the study information
| 2016 | Year | 08 | Month | 29 | Day |
Related information
URL releasing protocol
UMIN000023816protocol
Publication of results
Published
Result
URL related to results and publications
UMIN000023816results
Number of participants that the trial has enrolled
8
Results
high-intensity resistance exercise (HRE) led to increased arterial stiffness and decreased cerebral blood flow (CBF). Moreover, a negative correlation was observed between CBF and arterial stiffness after exercise. These results suggested that increased arterial stiffness with HRE influenced a reduction in CBF.
Results date posted
| 2022 | Year | 07 | Month | 02 | Day |
Results Delayed
Results Delay Reason
Date of the first journal publication of results
Baseline Characteristics
healthy subjects
Participant flow
informed consent
confirmed training frequency
performed measuring
Adverse events
no
Outcome measures
arterial stiffness
cerebral blood flow
Plan to share IPD
IPD sharing Plan description
Progress
Recruitment status
Completed
Date of protocol fixation
| 2016 | Year | 08 | Month | 29 | Day |
Date of IRB
| 2016 | Year | 08 | Month | 29 | Day |
Anticipated trial start date
| 2016 | Year | 08 | Month | 29 | Day |
Last follow-up date
| 2017 | Year | 03 | Month | 31 | Day |
Date of closure to data entry
Date trial data considered complete
Date analysis concluded
Other
Other related information
Management information
Registered date
| 2016 | Year | 08 | Month | 29 | Day |
Last modified on
| 2022 | Year | 07 | Month | 02 | Day |
Link to view the page
Value
https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000027436
