Unique ID issued by UMIN | UMIN000022795 |
---|---|
Receipt number | R000026273 |
Scientific Title | A study on online registry of healthy volunteers and subjects with preclinical Alzheimer's disease for the prevention of dementia |
Date of disclosure of the study information | 2016/06/20 |
Last modified on | 2021/06/24 09:56:20 |
A study on online registry of healthy volunteers and subjects with preclinical Alzheimer's disease for the prevention of dementia
Online regitry of healthy volunteers for the prevention of dementia
A study on online registry of healthy volunteers and subjects with preclinical Alzheimer's disease for the prevention of dementia
Online regitry of healthy volunteers for the prevention of dementia
Japan |
healthy volunteer
Adult |
Others
NO
With the rapid aging of the global population, cognitive decline and dementia pose large-scale healthcare and socioeconomic burdens. Strategies to address these burdens are urgently needed, particularly for dementia due to Alzheimer's disease (AD). Such strategies include the development of disease modifying therapies (DMT) for AD but must also incorporate a preventive approach to reducing risk factors. Over the past 10 years, AD DMT clinical trials have been largely unsuccessful, partly due to difficulty in recruiting early stage patients for enrollment. In addition, successful AD prevention trials will require a better understanding of the complex relationships between cognitive and functional abilities, risk factors, and life style choices. Establishing a large-scale registry for healthy and at risk individuals will play a key role in efficiently addressing these issues.
Others
To investigate relationship between lifestyle and dementia
Exploratory
Longitudinal measures of memory performance index
Observational
40 | years-old | <= |
Not applicable |
Male and Female
People to understand the Japanese over the age of 40
People under the age of 40
30000
1st name | Hiroshi |
Middle name | |
Last name | Matsuda |
National Center of Neurology and Psychiatry
Integrative Brain Imaging Center
187-8551
4-1-1, Ogawahigashi, Kodaira
0423412712
matsudah@ncnp.go.jp
1st name | Hiroshi |
Middle name | |
Last name | Matsuda |
National Center of Neurology and Psychiatry
Integrative Brain Imaging Center
187-8551
4-1-1, Ogawahigashi, Kodaira
0423412712
matsudah@ncnp.go.jp
National Center of Neurology and Psychiatry
Japan Agency for Medical Research and Development
Japanese Governmental office
National Center of Neurology and Psychiatry
4-1-1, Ogawahigashi, Kodaira
0423412711
rinri-jimu@ncnp.go.jp
NO
2016 | Year | 06 | Month | 20 | Day |
Partially published
Ogawa M, et al. Alzheimers Dement (NY) 5:347-353,2019
5700
This study assessed the longitudinal changes in the collated data for predicting the risk of dementia and included 473 individuals registered in the IROOP who completed the initial questionnaire and brief assessment of cognitive function (MCI Screen) at baseline and the regular questionnaire and the MCI Screen at least once after baseline.
Mood, sleep, quality of life, and medical histories including cognition were found to influence longitudinal changes in cognitive function.
2019 | Year | 12 | Month | 24 | Day |
2019 | Year | 08 | Month | 02 | Day |
Completed
2016 | Year | 03 | Month | 02 | Day |
2016 | Year | 03 | Month | 02 | Day |
2016 | Year | 07 | Month | 05 | Day |
2021 | Year | 03 | Month | 17 | Day |
2021 | Year | 03 | Month | 17 | Day |
2021 | Year | 03 | Month | 17 | Day |
2021 | Year | 03 | Month | 17 | Day |
We have developed a nation-wide, online registry system for healthy or at risk individuals over 40 years old in Japan. Every 6 months, registered participants answer an online questionnaire including demographics, mood, quality of life, sleep,and so on, and take a brief neuropsychological assessment (MCI Screen) over the phone. The MCIS includes the well-validated 10-word recall protocol used in the CERAD and ADAS-Cog batteries.
2016 | Year | 06 | Month | 20 | Day |
2021 | Year | 06 | Month | 24 | Day |
Value
https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000026273