Unique ID issued by UMIN | UMIN000022699 |
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Receipt number | R000026161 |
Scientific Title | Effects of preprandial administration of high-dose metformin on postprandial hypertriglyceridemia. |
Date of disclosure of the study information | 2016/06/13 |
Last modified on | 2018/06/28 08:37:11 |
Effects of preprandial administration of high-dose metformin on postprandial hypertriglyceridemia.
Effects of preprandial administration of high-dose metformin on postprandial hypertriglyceridemia.
Effects of preprandial administration of high-dose metformin on postprandial hypertriglyceridemia.
Effects of preprandial administration of high-dose metformin on postprandial hypertriglyceridemia.
Japan |
Type 2 diabetes mellitus
Endocrinology and Metabolism |
Others
NO
To investigate the effects of metformin on changes in postprandial serum triglyceride concentrations between postprandial and preprandial administration.
Efficacy
Changes in postprandial serum triglyceride concentrations between postprandial and preprandial administration
Changes of following parameters between postprandial and preprandial administration
1) plasma glucose, plasma insulin, GLP-1
2) Visual analyzing score of gastrointestinal symptoms and satiety
Interventional
Cross-over
Randomized
Individual
Open -but assessor(s) are blinded
Active
NO
NO
Institution is not considered as adjustment factor.
NO
Central registration
2
Treatment
Medicine |
Oral administration of 500-1000 mg metformin before test meal
Oral administration of 500-1000 mg metformin after test meal
20 | years-old | <= |
70 | years-old | > |
Male and Female
1) Aged >= 20, <70 at consent
2) In-patients with type2 diabetes at shiga universuty hospital with 500-1000 mg per single dose of metformin
3) Random non-fasting Triglyceride > 150mg/dl and < 1000mg/dl
4) Provided written informed consent
1) Receiving drugs that affect gastrointestinal motility (Glucagon-like peptide-1 analogue, or anticholinergic drug, etc.)
2) Has history of pancreatitis
3) With severe autonomic dysfunction (orthostatic hypotension, or neurogenic bladder, etc.)
4) Has history of intestinal obstruction after upper gastrointestinal surgery or hepato-biliary-pancreatic surgery
5) Receiving treatment for cancers
6) During pregnancy or lactation
7) With contraindications to metformin (history of lactic acidosis, or moderate and severe renal impairment, etc.)
8) Considered inadequate by the investigator
10
1st name | |
Middle name | |
Last name | Katsutaro Morino |
Shiga University of Medical Science
Department of Medicine, Division of Diabetes, Nephrology and Neurology
Seta Tsukinowa-cho, Otsu-city, Shiga, Japan 520-2192
077-548-2222
morino@belle.shiga-med.ac.jp
1st name | |
Middle name | |
Last name | Katsutaro Morino |
Shiga University of Medical Science
Department of Medicine, Division of Diabetes, Nephrology and Neurology
Seta Tsukinowa-cho, Otsu-city, Shiga, Japan 520-2192
077-548-2222
http://www.shiga-med.ac.jp/hospital/doc/department/department/secretion/index.html
morino@belle.shiga-med.ac.jp
Shiga University of Medical Science
Shiga University of Medical Science Management Expenses Grants
Other
Japan
NO
滋賀医科大学附属病院(滋賀県)
2016 | Year | 06 | Month | 13 | Day |
Unpublished
Completed
2016 | Year | 03 | Month | 22 | Day |
2016 | Year | 06 | Month | 13 | Day |
2016 | Year | 06 | Month | 11 | Day |
2018 | Year | 06 | Month | 28 | Day |
Value
https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000026161
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