Unique ID issued by UMIN | UMIN000021802 |
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Receipt number | R000025009 |
Scientific Title | Research for elucidating the resistance mechanism to RET tyrosine kinase inhibitors in patients with non-small-cell lung cancer harboring with RET fusion gene |
Date of disclosure of the study information | 2016/04/12 |
Last modified on | 2016/10/11 12:09:12 |
Research for elucidating the resistance mechanism to RET tyrosine kinase inhibitors in patients with non-small-cell lung cancer harboring with RET fusion gene
Research for RET-TKI resistance in NSCLC harboring with RET fusion gene
Research for elucidating the resistance mechanism to RET tyrosine kinase inhibitors in patients with non-small-cell lung cancer harboring with RET fusion gene
Research for RET-TKI resistance in NSCLC harboring with RET fusion gene
Japan |
Advanced non-small-cell lung cancer harboring with RET fusion gene
Pneumology |
Malignancy
YES
To elucidate the resistance mechanism to RET-TKI alectinib in NSCLC harboring with RET fusion gene
Others
To elucidate the resistance mechanism to RET-TKI alectinib in NSCLC harboring with RET fusion gene using clinical sample before and after alectinib
Exploratory
Not applicable
To find out the resistance mechanism to RET-TKI alectinib in NSCLC harboring with RET fusion gene
Observational
20 | years-old | <= |
Not applicable |
Male and Female
1. Written informed consent
2. Histologically or cytologically diagnosed NSCLC
3. Unresectable locally advanced or metastatic disease
4. Tumor samples test positive for a RET fusion gene
5. Testing negative for an EGFR mutation
6. Testing negative for an ALK fusion gene
1. Having previously received alectinib
2.Patients whom an investigator deems ineligible for participation in this study for some other reason.
30
1st name | |
Middle name | |
Last name | Seiji Yano |
Cancer Research Institute, Kanazawa University
Medical Oncology
13-1 Takara-machi, Kanazawa, Ishikawa 920-0934
076-265-2794
syano@staff.kanazawa-u.ac.jp
1st name | |
Middle name | |
Last name | Tadaaki Yamada |
Cancer Research Institute, Kanazawa University
Medical Oncology
13-1 Takara-machi, Kanazawa, Ishikawa 920-0934
076-265-2794
tadaakiy@staff.kanazawa-u.ac.jp
Cancer Research Institute, Kanazawa University
Japan Agency for Medical Research and Development (AMED)
Other
Japan
Hokkaido University
National Cancer Center Hospital East
The Cancer Institute Hospital of JFCR
Tokyo University
Nagoya University Hospital
Hyogo Cancer Center
Okayama University Hospital
National Hospital Organization Kyushu Cancer Center
NO
北海道大学大学院医学系研究科(北海道)
国立がん研究センター東病院(千葉県)
がん研究会有明病院(東京都)
東京大学大学院医学系研究科(東京都)
名古屋大医学部附属病院(愛知県)
金沢大学附属病院(石川県)
兵庫県立がんセンター(兵庫県)
岡山大学病院(岡山県)
国立病院機構 九州がんセンター(福岡県)
2016 | Year | 04 | Month | 12 | Day |
Unpublished
Enrolling by invitation
2016 | Year | 02 | Month | 17 | Day |
2016 | Year | 05 | Month | 09 | Day |
2020 | Year | 12 | Month | 31 | Day |
2020 | Year | 12 | Month | 31 | Day |
2020 | Year | 12 | Month | 31 | Day |
2020 | Year | 12 | Month | 31 | Day |
To elucidate the resistance mechanism to RET-TKI alectinib using DNA, RNA, and proteins derived from clinical samples in patients with non-small-cell lung cancer harboring with RET fusion gene
2016 | Year | 04 | Month | 06 | Day |
2016 | Year | 10 | Month | 11 | Day |
Value
https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000025009
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