Unique ID issued by UMIN | UMIN000021623 |
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Receipt number | R000024937 |
Scientific Title | Effects of ipragliflozin on body composition and beta-cell function in Japanese patients with type 2 diabetes |
Date of disclosure of the study information | 2016/03/27 |
Last modified on | 2016/04/19 18:59:00 |
Effects of ipragliflozin on body composition and beta-cell function in Japanese patients with type 2 diabetes
Effects of ipragliflozin on body composition and beta-cell function
Effects of ipragliflozin on body composition and beta-cell function in Japanese patients with type 2 diabetes
Effects of ipragliflozin on body composition and beta-cell function
Japan |
Type 2 diabetes
Endocrinology and Metabolism |
Others
NO
The aim of this study is to clarify the effect of an SGLT2 inhibitor (ipraglifrozin) on body composition and beta-cell function.
Safety
%Change of visceral fat volume assessed by CT and %change of intrahepatic lipid content assessed by 1H-MRS at 0-, 12- and 24-week of ipraglifrozin treatment
beta-cell stress assessed by the change of plasma intact proinsulin / C-peptide (PI/CPR) ratio at 0-, 12- and 24-week of ipraglifrozin treatment
Interventional
Single arm
Non-randomized
Open -no one is blinded
Self control
1
Treatment
Medicine |
ipraglifrozin 50mg/day for 24 weeks
20 | years-old | <= |
80 | years-old | >= |
Male and Female
Outpatients
HbA1c >= 6.5%
20 <= BMI <= 40
The exclusion criteria were pregnancy, severe illness, CKD (eGFR < 60 ml/min/1.73m2), and malignancy.
20
1st name | |
Middle name | |
Last name | Yasushi Tanaka |
St. Marianna University School of Medicine
Division of Metabolism and Endocrinology, Department of Internal Medicine
2-16-1 Sugao, Miyamae-ku, Kawasaki, Kanagawa 216-8511, Japan
044-977-8111
smu.tainai@gmail.com
1st name | |
Middle name | |
Last name | Yoshio Nagai |
St. Marianna University School of Medicine
Division of Metabolism and Endocrinology, Department of Internal Medicine
2-16-1 Sugao, Miyamae-ku, Kawasaki, Kanagawa 216-8511, Japan
044-977-8111
ynagai@marianna-u.ac.jp
St. Marianna University School of Medicine
None
Self funding
NO
2016 | Year | 03 | Month | 27 | Day |
Unpublished
Completed
2014 | Year | 06 | Month | 24 | Day |
2014 | Year | 07 | Month | 01 | Day |
2016 | Year | 03 | Month | 26 | Day |
2016 | Year | 04 | Month | 19 | Day |
Value
https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000024937
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