Unique ID issued by UMIN | UMIN000020816 |
---|---|
Receipt number | R000024016 |
Scientific Title | Study of the link between Dopamine Transporter Gene Polymorphisms and Response To Paroxetin and Escitalopram in Patients With Lifelong Premature Ejaculation |
Date of disclosure of the study information | 2016/02/01 |
Last modified on | 2017/08/11 07:16:17 |
Study of the link between Dopamine Transporter Gene Polymorphisms and Response To Paroxetin and Escitalopram in Patients With Lifelong Premature Ejaculation
Dopamine transporter gene polymorphisms and SSRIs
Study of the link between Dopamine Transporter Gene Polymorphisms and Response To Paroxetin and Escitalopram in Patients With Lifelong Premature Ejaculation
Dopamine transporter gene polymorphisms and SSRIs
Africa |
lifelong premature ejaculation
Urology | Adult |
Others
YES
to assess role of dopamine gene transporter polymorphisms in lifelong premature ejaculation and their responses to selective serotonin reuptake inhibitors
Safety,Efficacy
Exploratory
Majority of dopamine transporter gene polymorphisms majority were 10R/10R and 6R/10R
At the end of our study we found 27 patients out of 60 patients responded to paroxetin and escitalopram. Both of them were statistically highly significant in delaying ejaculation in the responders.Also, they demonstrated statistically highly significant relation with dopamine transporter gene polymorphism
Interventional
Parallel
Non-randomized
Open -no one is blinded
No treatment
2
Treatment
Medicine |
The patients were divided into 2 equal groups; one group was given paroxetine and the other escitalopram single dose daily for 3 months to compare efficacy of both drugs in delaying ejaculation in patients with lifelong PE. Also, to evaluate role of the studied gene polymorphisms in lifelong PE and determining response to both drugs
we only measured gene polymorphisms in the controls. The controls were not given medication
25 | years-old | <= |
50 | years-old | >= |
Male
The patients' age was between 25-50 years with a stable and continuous marital relationship for at least one year. Condoms, topical anesthetic cream or spray before sexual intercourse were prohibited, being unable to satisfy their partners with intravaginal ejaculation latency time < 1 minute since their first sexual experience on all or nearly all vaginal penetrations with negative personal consequences on him and his partner and subsequent avoidance of sexual intimacy.
Men suffered from ED (IIEF score< 21), reduced sexual desire or inhibited male orgasm. Also, patients with history of urinary tract infection, mental disorders and chronic physical illnesses affecting ejaculatory function, abusers of Alcohol or drug and finally, patients who received psychotropic medications that may affect response to selective serotonin reuptake inhibitors (SSRIs) or any medical treatment for premature ejaculation in the last 6 months were also excluded from the study.
80
1st name | |
Middle name | |
Last name | tymour khalifa Eltonsi |
Al-Azhar university
andrology and dermatology
Al-Azhar Street
+81-1222182039
tarek_tawfik117@yahoo.com
1st name | |
Middle name | |
Last name | Sameh Fayek |
Cairo University
Andrology department
Kasr AlAini street
+81-1227109309
http://scholar.cu.edu.eg/sfayek
samehfayek@hotmail.com
nil
EVA and MEPACO pharmaceutical companies
Other
Egypt
nil
nil
NO
Al-Azhar and Cairo Universities
2016 | Year | 02 | Month | 01 | Day |
Published
Our prospective study revealed that 18 patients were LL, 42 patients were SL and SS genotypes of the serotonin transporter gene promoter polymorphism, meanwhile; the controls were 10 LL, 6 SL and 4 SS which was statistically insignificant (p-value=0.265). Thirty seven patients were 10R/10R, 17 patients were 6R/10R and 6 patients were 6R/6R genotypes of the dopamine transporter gene polymorphism, meanwhile; the controls were 15 6R/6R, 1 10R/10R and 4 6R/10R which was statistically significant (p-value=<0.001). Both paroxetin and escitalopram were highly statistically significant in delaying ejaculation in the responders (p-value=<0.001). This response was irrelevant to serotonin transporter gene promoter polymorphism (p-value= 0.275), meanwhile; such response revealed highly statistically significant relation with dopamine transporter gene polymorphism (p-value=0.019).
Main results already published
2014 | Year | 09 | Month | 15 | Day |
2014 | Year | 10 | Month | 27 | Day |
2015 | Year | 12 | Month | 01 | Day |
2015 | Year | 12 | Month | 15 | Day |
2015 | Year | 12 | Month | 15 | Day |
2016 | Year | 01 | Month | 05 | Day |
2016 | Year | 02 | Month | 01 | Day |
2017 | Year | 08 | Month | 11 | Day |
Value
https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000024016