Unique ID issued by UMIN | UMIN000018677 |
---|---|
Receipt number | R000021599 |
Scientific Title | Investigation of the efficacy of read-through therapy for Nagashima-type palmoplantar keratosis using topical aminoglycoside |
Date of disclosure of the study information | 2015/09/01 |
Last modified on | 2018/02/14 14:08:06 |
Investigation of the efficacy of read-through therapy for Nagashima-type palmoplantar keratosis using topical aminoglycoside
Read-through therapy for Nagashima-type palmoplantar keratosis
Investigation of the efficacy of read-through therapy for Nagashima-type palmoplantar keratosis using topical aminoglycoside
Read-through therapy for Nagashima-type palmoplantar keratosis
Japan |
Nagashima-type palmoplantar keratosis
Dermatology |
Others
YES
We investigate the efficacy of read-through therapy using 0.1% gentamicin ointment in patients with NPPK.
Efficacy
Exploratory
1.Improvement of skin symptoms such as erythema and hyperkeratosis.
2.Participants' self-assessment of improvement by VAS (Visual Analogue Scale).
We evaluate skin symptoms 4 weeks after the treatment.
Interventional
Cross-over
Randomized
Individual
Open -but assessor(s) are blinded
Placebo
2
Treatment
Medicine |
The patients apply vaseline or 0.1% gentamicin topically to one of the hands with erythema and hyperkeratosis twice a day for 4 weeks.
The patients apply vaseline or 0.1% gentamicin topically to one of the hands with erythema and hyperkeratosis twice a day for 4 weeks.
1 | years-old | <= |
Not applicable |
Male and Female
NPPK patients at the Hokkaido University hospital who fulfill the following criteria:
1.Patients aged 1 or older at the time of informed consent.
2.Patients who are homozygous or heterozygous for the mutation c.796C>T in SERPINB7.
3.Patients showing erythema and hyperkeratosis on both hands.
4.Patients giving written informed consent.
1.Patients who meet exclusion criteria of the drug.
2.Patients with severe complications who need hospitalization.
3.Patients who is considered to be inappropriate for this study.
6
1st name | |
Middle name | |
Last name | Toshifumi Nomura |
Hokkaido University Hospital
Department of Dermatology
North 14 West 5, Kita-ku, Sapporo 060-8648, Japan
011-716-1161
nomura@huhp.hokudai.ac.jp
1st name | |
Middle name | |
Last name | Yuka Ohguchi |
Hokkaido University Graduate School of Medicine
Department of Dermatology
North 15 West 7, Kita-ku, Sapporo 060-8638, Japan
011-706-7387
yu-ohguchi@keb.biglobe.ne.jp
Hokkaido University Hospital
None
Self funding
NO
2015 | Year | 09 | Month | 01 | Day |
Published
Completed
2015 | Year | 08 | Month | 11 | Day |
2015 | Year | 09 | Month | 01 | Day |
2015 | Year | 08 | Month | 14 | Day |
2018 | Year | 02 | Month | 14 | Day |
Value
https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000021599