Unique ID issued by UMIN | UMIN000017081 |
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Receipt number | R000019815 |
Scientific Title | Comparison of intravitreal ranibizumab injection with or without tissue plasminogen activator in the treatment of type 2 choroidal neovascularization |
Date of disclosure of the study information | 2015/04/10 |
Last modified on | 2015/04/08 20:59:02 |
Comparison of intravitreal ranibizumab injection with or without tissue plasminogen activator in the treatment of type 2 choroidal neovascularization
Effect of tissue plasminogen activator on type 2 choroidal neovascularization
Comparison of intravitreal ranibizumab injection with or without tissue plasminogen activator in the treatment of type 2 choroidal neovascularization
Effect of tissue plasminogen activator on type 2 choroidal neovascularization
Japan |
neovascular age-related macular degeneration
Ophthalmology |
Others
NO
Anti-vascular endothelial growth factor (VEGF) therapies can effectively suppress development and progression of choroidal neovascularization (CNV). However, they possess little ability to regress once-developed fibrovascular tissue. The purpose of this study is to evaluate the impacts of fibrinolysis with Tissue plasminogen activator (tPA) on type 2 CNV.
Efficacy
Best-corrected visual acuities (BCVAs)
Central retinal thickness
Macular volume
The ILM-RPE thickness at the thickest point of the subretinal fibrinous and/or fibrovascular tissues
Parallel
Non-randomized
Open -no one is blinded
Active
2
Treatment
Medicine |
intravitreal injection of tPA combined with intravitreal ranibizumab
intravitreal ranibizumab
50 | years-old | <= |
Not applicable |
Male and Female
Age related macular degeneration with type 2 choroidal neovascularization,
previous treatments involving laser photocoagulation or photodynamic therapy
20
1st name | |
Middle name | |
Last name | Tsutomu Yasukawa |
Nagoya City University Graduate School of Medical Sciences
Department of Ophthalmology and Visual Science
1 Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya 467-8601, JAPAN
052-853-8251
yasukawa@med.nagoya-cu.ac.jp
1st name | |
Middle name | |
Last name | Tsutomu Yasukawa |
Nagoya City University Graduate School of Medical Sciences
Department of Ophthalmology and Visual Science
1 Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya 467-8601, JAPAN
052-853-8251
yasukawa@med.nagoya-cu.ac.jp
Department of Ophthalmology and Visual Science
Nagoya City University Graduate School of Medical Sciences
none
Self funding
NO
2015 | Year | 04 | Month | 10 | Day |
Partially published
Completed
2010 | Year | 03 | Month | 01 | Day |
2010 | Year | 04 | Month | 01 | Day |
2015 | Year | 04 | Month | 08 | Day |
2015 | Year | 04 | Month | 08 | Day |
Value
https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000019815
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