Unique ID issued by UMIN | UMIN000016761 |
---|---|
Receipt number | R000019269 |
Scientific Title | Skin test and flow cytometry in healthy volunteers to establish the method for determining causative drug of perioperative anaphylaxis: A preliminary study |
Date of disclosure of the study information | 2015/03/10 |
Last modified on | 2017/03/14 08:55:17 |
Skin test and flow cytometry in healthy volunteers to establish the method for determining causative drug of perioperative anaphylaxis: A preliminary study
Skin test and flow cytometry in healthy volunteers
Skin test and flow cytometry in healthy volunteers to establish the method for determining causative drug of perioperative anaphylaxis: A preliminary study
Skin test and flow cytometry in healthy volunteers
Japan |
Anaphylaxis
Anesthesiology | Adult |
Others
NO
Although skin test has been widely used for identifying causative drug of anaphylaxis, it has some disadvantages including a risk of recurrent anaphylaxis and pain. The purpose this study is to establish an ideal tool for determing causative drug of perioperative anaphylaxis. For this purpose, we will focus on basophil activate test (BAT) with flow cytometry as an alternative to skin test. We will seek the maximum concentration not to see pseudo-positive reaction in healthy volunteers.
Safety
Seeking the optimum concentration of drugs for skin test and BAT
Interventional
Single arm
Non-randomized
Open -no one is blinded
Uncontrolled
1
Diagnosis
Medicine |
Histamin as a positive control
Normal saline as a negative control
Suspected drugs including sugamamdex and cephazolin
20 | years-old | <= |
Not applicable |
Male and Female
1) A volunteer who is 20 years or older
2) Avolunteer whose written consent has been obtained regarding participation in this study
1)A pregnant woman /A patient who has a possibility of pregnancy
2)A volunteer taking beta blocker
3)A volunteer taking steroid
4)A volunteer with past history of perioperative anaphylaxis
5)A volunteer to whom a doctor judged inappropriate for participating in this study
30
1st name | |
Middle name | |
Last name | Shigeru SAITO |
Gunma University Hospital
Department of Anesthesiology
3-39-15 Showa-machi, Maebashi , Gunma, Japan 371-8511
027-220-8454
shigerus@gunma-u.ac.jp
1st name | |
Middle name | |
Last name | Tomonori TAKAZAWA |
Gunma University Hospital
Department of Anesthiology
3-39-15 Showa-machi, Maebashi , Gunma, Japan 371-8511
027-220-8454
takazawt@gunma-u.ac.jp
Gunma University Hospital, Department of Anesthesiology
Japan Society for the Promotion of Science
Japanese Governmental office
NO
2015 | Year | 03 | Month | 10 | Day |
Unpublished
Open public recruiting
2015 | Year | 02 | Month | 24 | Day |
2015 | Year | 03 | Month | 11 | Day |
To estimate the optimum concentration of the perioperative agent for a skin test and BAT
2015 | Year | 03 | Month | 10 | Day |
2017 | Year | 03 | Month | 14 | Day |
Value
https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000019269