Unique ID issued by UMIN | UMIN000035127 |
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Receipt number | R000019143 |
Scientific Title | The cohort study for live-style associated liver disease |
Date of disclosure of the study information | 2018/12/05 |
Last modified on | 2020/11/02 12:27:59 |
The cohort study for live-style associated liver disease
The cohort study for live-style associated liver disease
The cohort study for live-style associated liver disease
The cohort study for live-style associated liver disease
Japan |
Fatty Liver
Endocrinology and Metabolism |
Others
NO
The aim of the study is to obtain the clinical features of subjects with non-alcoholic fatty liver disease. In this study, we perform a prospective and a retrospective cohort study aiming to prevent the progression of nonalcoholic steatohepatitis (NASH). For the purpose, we analyze the clinical data registered in the study and find clinical features associated with the progression of nonalcoholic steatohepatitis (NASH) and find clinical features, by which we can predict a high risk group of NASH.
Others
Epidemiology of fatty liver.
The change of the controlled attenuation parameter (CAP) and liver stiffness measurement (LSM) determined by FibroScan (Echosens, Paris, France).
Observational
20 | years-old | <= |
Not applicable |
Male and Female
Receiving Fibro scan.
Refusal or lacks capacity to give informed consent to participate in the trial.
2000
1st name | Michiaki |
Middle name | |
Last name | Fukui |
Kyoto Prefectural University of Medicine Graduate School of Medical Science
Department of Endocrinology and Metabolism
602-8566
465, Kajii-cho, Kawaramachi-Hirokoji, Kamigyo-ku
+81-75-251-5505
michiaki@koto.kpu-m.ac.jp
1st name | Masahide |
Middle name | |
Last name | Hamaguchi |
Kyoto Prefectural University of Medicine Graduate School of Medical Science
Department of Endocrinology and Metabolism
602-8566
465, Kajii-cho, Kawaramachi-Hirokoji, Kamigyo-ku
+81-75-251-5506
mhama@koto.kpu-m.ac.jp
Kyoto Prefectural University of Medicine Graduate School of Medical Science
Self funding
Self funding
Kyoto Prefectural University of Medicine, Clinical Research Review Board
Kawaramachi-Hirokoji, Kamigyo-ku, Kyoto, 602-8566
075-251-5337
rinri@koto.kpu-m.ac.jp
NO
2018 | Year | 12 | Month | 05 | Day |
https://www.sciencedirect.com/science/article/pii/S1499267120300770?via%3Dihub
Published
https://www.sciencedirect.com/science/article/pii/S1499267120300770?via%3Dihub
246
LSM was associated with changes in UAE (r<0.27,p<0.005). Multiple regression analysis demonstrated that LSM was associated with change in UAE (b=0.28,p<0.015) after adjusting for co-variate.
2020 | Year | 08 | Month | 11 | Day |
2019 | Year | 03 | Month | 23 | Day |
Mean (standard deviation) data were as follows: age, 63.3 (12.1) years;body mass index, 25.4 (4.3)kg/m2; controlled attenuation parameter, 273.1 (53.0) dB/m; and LSM, 6.2 (3.4) kPa. Median UAE value(interquartile range) was 16 (6 to 43) mg/g creatinine.
Our study enrolled 246 patients (140 men and 106 women).Among these 246 patients, 72 men and 31 women were excluded.Thus, 143 patients (68 men and 75 women) were included in this study. Twenty-six patients (9 men and 17 women) did not undergo follow-up examination. Moreover, 12 patients with kidney disease with at least stage 3 nephropathy were excluded from the study.Thus, we investigated 105 patients (52 men and 53 women)
No
The association between LSM with change in UAE.
Completed
2015 | Year | 03 | Month | 02 | Day |
2015 | Year | 03 | Month | 02 | Day |
2015 | Year | 03 | Month | 02 | Day |
2016 | Year | 08 | Month | 31 | Day |
2017 | Year | 12 | Month | 15 | Day |
2017 | Year | 12 | Month | 19 | Day |
2019 | Year | 07 | Month | 16 | Day |
Prospective and retrospective study.
Outpatient in University Hospital, Kyoto Prefectural University of Medicine
First subject in 2015/03/02
Last Subject in 2025/3/31
2018 | Year | 12 | Month | 04 | Day |
2020 | Year | 11 | Month | 02 | Day |
Value
https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000019143
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