Unique ID issued by UMIN | UMIN000015618 |
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Receipt number | R000018152 |
Scientific Title | Research that focus on Multiliniage-differentiating stress enduring cells(Muse cells) for the treatment with mesenchymal stem cells in acute severe diseases |
Date of disclosure of the study information | 2014/11/07 |
Last modified on | 2021/11/15 08:57:47 |
Research that focus on Multiliniage-differentiating stress enduring cells(Muse cells) for the treatment with mesenchymal stem cells in acute severe diseases
Research for Muse cells in acute severe diseases
Research that focus on Multiliniage-differentiating stress enduring cells(Muse cells) for the treatment with mesenchymal stem cells in acute severe diseases
Research for Muse cells in acute severe diseases
Japan |
sepsis, trauma, burn, post-cardiac arrest syndrome, rhabdomyolysis
Surgery in general | Emergency medicine | Intensive care medicine |
Others
NO
To reveal the Muse cells kinetics in acute severe diseases and to research the potential of cell-based therapy for acute invasive pathology by analyzing relationship Muse cells with outcome, severity, and damage-associated molecular patterns and inflammatory mediators from the aspects of function as repair cells and the trophic effects
Others
Exploration
Exploratory
Others
Not applicable
We evaluate the Muse cells in acute severe diseases. 1) Quantitative assessment of peripheral blood Muse cells: the quantification by flow cytometry, 2) Isolation of Muse cells, culture, form / function analysis
In addition, it clarifies the association the dynamics of Muse cells with outcome, severity and damage-associated molecular patterns and inflammatory mediators.
Observational
Not applicable |
Not applicable |
Male and Female
a)Of the patients who were hospitalized in the Tohoku University Hospital Emergency center, trauma; Abbreviated Injury Score (AIS) 3 or more, burn; total burn surface area(TBSA) more than 10%, sepsis; severe sepsis, rhabdomyolysis; CK 5,000 or more, post-cardiac arrest syndrome; out-of-hospital cardiac arrest patients requiring hospital treatment with return of spontaneous circulation by resuscitation
b)healthy person
Patients or family do not agree to participate in this study.
30
1st name | Shigeki |
Middle name | |
Last name | Kushimoto |
Tohoku University Graduate School of Medicine
Division of Emergency and Critical Care Medicine
980-8574
1-1 Seiryo-machi, Aoba-ku, Sendai, 980-8574, Japan
022-717-7489
information@emergency-medicine.med.thoku.ac.jp
1st name | Tetsuya |
Middle name | |
Last name | Sato |
Tohoku University Graduate School of Medicine
Division of Emergency and Critical Care Medicine
980-8574
1-1 Seiryo-machi, Aoba-ku, Sendai, 980-8574, Japan
022-717-7489
t23jor@med.tohoku.ac.jp
Division of Emergency and Critical Care Medicine, Tohoku University Graduate School of Medicine
None
Self funding
Department of Stem Cell Biology and Histology, Tohoku University Graduate School of Medicine
Tohoku University Graduate School of Medicine Institutional Review Board
2-1 Seiryo-machi, Aoba-ku, Sendai, 980-8575, Japan
022-728-4105
med-kenkyo@grp.tohoku.ac.jp
NO
2014 | Year | 11 | Month | 07 | Day |
Unpublished
Terminated
2014 | Year | 11 | Month | 05 | Day |
2014 | Year | 11 | Month | 05 | Day |
2014 | Year | 12 | Month | 01 | Day |
2020 | Year | 03 | Month | 31 | Day |
Blood is collected within 24 hours after the visit, 48 hours, 72 hours, day 7, day 14, day28 or before discharge. We evaluate the dynamics of Muse cells, and consider the relationship with the patient background factors, severity score, damage-associated molecular patterns, inflammatory mediators, fibrinolytic system parameters, and cell mediated immunity.
2014 | Year | 11 | Month | 06 | Day |
2021 | Year | 11 | Month | 15 | Day |
Value
https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000018152
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