Unique ID issued by UMIN | UMIN000015522 |
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Receipt number | R000018031 |
Scientific Title | Effect of glycemic control using glucose-insulin infusion on postoperative inflammatory responses, renal function, complications, and outcomes in major oral and maxiilfacial surgery |
Date of disclosure of the study information | 2014/10/25 |
Last modified on | 2016/04/25 18:41:29 |
Effect of glycemic control using glucose-insulin infusion on postoperative inflammatory responses, renal function, complications, and outcomes in major oral and maxiilfacial surgery
Effect of glycemic control during oral and maxillofacial surgery on postoperative inflammatory responses and outcome
Effect of glycemic control using glucose-insulin infusion on postoperative inflammatory responses, renal function, complications, and outcomes in major oral and maxiilfacial surgery
Effect of glycemic control during oral and maxillofacial surgery on postoperative inflammatory responses and outcome
Japan |
Patients who are schduled for radical operation of oral malignant tumors along with tissue reconstruction
Dental medicine | Adult |
Malignancy
NO
The purpose of this study is to clarify the effect of intraoperative glycemic control by glucose-insulin infusion on postoperative inflammatory responses, renal function, postoperative systemic complications and outcomes in patients undergoing major oral and maxillofacial surgeries, which requires tissue reconstruction.
Safety,Efficacy
It is supposed that postoperative inflammatory responses, postoperative complications, and days required until discharge may be reduced by intraoperative glucose-insulin infusion.
Interventional
Parallel
Randomized
Individual
Single blind -participants are blinded
Active
2
Treatment
Medicine |
Regular insulin was continuously applied along with infusion of glucose-containing acetate Ringer's solution (10g glucose per 500mL) during surgery, and blood glucose wa adjusted within the target concentration of 80 - 120 mg/dL.
Acetate Ringer's solution, which contains 1% (W/V) glucose or lactate Ringer's solution, which does not contain glucose, was infused, and regular insulin is applied each time when a blood glucose concentration is 180mg/dL or more.
60 | years-old | <= |
Not applicable |
Male and Female
Patients with ASA physical status 1-2 and those who are scheduled for radical operations of oral malignant tumors with tissue reconstruction.
Patients whose operation time is less than 8H or those who were not able to continue insulin infusion due to hypoglycemia.
50
1st name | |
Middle name | |
Last name | Atsushi Kohjitani |
Kagoshima University Medical and Dental Hospital
Dental Anesthesiology
8-35-1 Kagoshima
099-275-6287
atsushik@dent.kagoshima-u.ac.jp
1st name | |
Middle name | |
Last name | Atsushi Kohjitani |
Kagoshima University Medical and Dental Hospital
Dental Anesthesiology
8-35-1 Kagoshima
099-275-6287
atsushik@dent.kagoshima-u.ac.jp
Kagoshima University Medical and Dental Hospintal
Kagoshima University
Other
NO
2014 | Year | 10 | Month | 25 | Day |
Partially published
Enrolling by invitation
2009 | Year | 04 | Month | 01 | Day |
2013 | Year | 01 | Month | 24 | Day |
2014 | Year | 10 | Month | 24 | Day |
2016 | Year | 04 | Month | 25 | Day |
Value
https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000018031
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