Unique ID issued by UMIN | UMIN000015345 |
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Receipt number | R000017851 |
Scientific Title | Induced pluripotent stem cell (iPSC)-derived immortalized megakaryocyte cell lines (imMKCLs) from voluntary blood component donors with specific HLA haplotypes towards platelet products in transfusion therapy. |
Date of disclosure of the study information | 2014/11/01 |
Last modified on | 2022/10/12 09:29:42 |
Induced pluripotent stem cell (iPSC)-derived immortalized megakaryocyte cell lines (imMKCLs) from voluntary blood component donors with specific HLA haplotypes towards platelet products in transfusion therapy.
Generation of transfusible platelets with specific HLA haplotypes from human iPSC-derived megakaryocyte cell lines
Induced pluripotent stem cell (iPSC)-derived immortalized megakaryocyte cell lines (imMKCLs) from voluntary blood component donors with specific HLA haplotypes towards platelet products in transfusion therapy.
Generation of transfusible platelets with specific HLA haplotypes from human iPSC-derived megakaryocyte cell lines
Japan |
Thrombocytopenia
Hematology and clinical oncology | Blood transfusion |
Others
YES
Aim of this study is (1) to establish iPSC-derived immortalized megakaryocyte cell lines from blood component donors with specific HLA haplotypes, and (2) to produce platelet product in vitro towards clinical use.
Others
Development of novel technologies towards clinical application by human stem cells
In vitro safety and functional studies by platelets generated from human iPSC-derived immortalized megakaryocyte cell lines
Observational
20 | years-old | <= |
Not applicable |
Male and Female
・Voluntary, non-remunerated, healthy blood component donors
・Homozygotes of HLA-A, HLA-B, and HLA-C
・Blood type O
・Individuals capable of giving voluntary, informed consent in writing
・The following viral infection:
Hepatic Virus B
Hepatic Virus C
Human Immunodeficiency Virus
Human T-cell leukemia virus
Human parvovirus B19
Cytomegalovirus
・The following microbial infection:
Treponema pallidum
West Nile Virus
Chlamydiaceae
Genus Neisseria
Mycobacterium
Malaria parasites(Plasmodium spp.)
Babesia
Trypanosoma cruzi
Leishmania
Trypanosoma brucei
・Malignant neoplasm
・Transmissible spongiform encephalopathy (including suspected case), Dementia or cognitive impairment, Stroke, Seizure
・The following conditions:
Particular or genetic/hereditary disorders
Severe or uncontrolled metabolic or endocrinal disorders
Connective tissue diseases
Severe or uncontrolled hematologic diseases
Severe or uncontrolled hepatic disorders
・Enrolling related studies of generating iPSC banks
3
1st name | Koji |
Middle name | |
Last name | Eto |
Center for iPS Cell Research and Application (CiRA), Kyoto University
Department of Clinical Application
606-8507
53 Kawahara-cho, Shogoin, Sakyo-ku, Kyoto 606-8507, Japan
075-366-7075
kojieto@cira.kyoto-u.ac.jp
1st name | Koji |
Middle name | |
Last name | Eto |
Center for iPS Cell Research and Application (CiRA), Kyoto University
Department of Clinical Application
606-8507
53 Kawahara-cho, Shogoin, Sakyo-ku, Kyoto 606-8507, Japan
075-366-7075
kojieto@cira.kyoto-u.ac.jp
・Center for iPS Cell Research and Application (CiRA), Kyoto University
・Kyoto University Hospital
Japan Science and Technology Agency (JST)
Government offices of other countries
Japan
Bioethics Committee of Kyoto University Graduate School of Medicine, Faculty of Medicine, and Kyoto University Hospital
Konoe-cho, Yoshida, Sakyo-ku, Kyoto, Kyoto
075-753-4680
ethcom@kuhp.kyoto-u.ac.jp
NO
京都大学医学部附属病院(Kyoto University Hospital)
2014 | Year | 11 | Month | 01 | Day |
Unpublished
Enrolling by invitation
2014 | Year | 09 | Month | 30 | Day |
2014 | Year | 12 | Month | 01 | Day |
2019 | Year | 03 | Month | 31 | Day |
Study of technological development for generating transfusible platelets from human iPSC-derived megakaryocyte cell lines
2014 | Year | 10 | Month | 06 | Day |
2022 | Year | 10 | Month | 12 | Day |
Value
https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000017851
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