Unique ID issued by UMIN | UMIN000015225 |
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Receipt number | R000017687 |
Scientific Title | Prospective observational study to clarify the effect of pneumococcal vaccine in interstitial lung disease patients with immunosuppressive therapy |
Date of disclosure of the study information | 2014/10/01 |
Last modified on | 2018/09/25 09:12:30 |
Prospective observational study to clarify the effect of pneumococcal vaccine in interstitial lung disease patients with immunosuppressive therapy
The effect of pneumococcal vaccine in interstitial lung disease patients with immunosuppressive therapy
Prospective observational study to clarify the effect of pneumococcal vaccine in interstitial lung disease patients with immunosuppressive therapy
The effect of pneumococcal vaccine in interstitial lung disease patients with immunosuppressive therapy
Japan |
interstitial lung disease
Pneumology | Infectious disease |
Others
NO
Interstitial lung disease is a refractory respiratory disease. It is preferable to perform the immunosuppressive therapy, and there often be complicated by severe infections.
To clarify the effect of pneumococcal vaccine in interstitial lung disease patients with immunosuppressive therapy.
Safety,Efficacy
We measure opsonic activity (OPA) and the rise of the antibody titer of the before and after vaccination.
We compare antibody titers, the rise of OPA in the non-treatment group and the immunosuppressive therapy group.
Observational
65 | years-old | <= |
Not applicable |
Male and Female
The target is interstitial lung disease patients in our hospital and all patients in Samani-cho Sanwa clinic
Patients who are vaccinated with pneumococcal vaccine within the last year
150
1st name | |
Middle name | |
Last name | Hiroki Takahashi |
Sapporo medical university
Respiratory medicine and allergology
nishi 17 choume minami 1jyo chuo-ku sapporo
(011)611-2111
kuronumak@sapmed.ac.jp
1st name | |
Middle name | |
Last name | Koji Kuronuma |
Sapporo medical university
Respiratory medicine and allergology
nishi 17 choume minami 1jyo chuo-ku sapporo
(011)611-2111
kuronumak@sapmed.ac.jp
Sapporo medical university
Respiratory medicine and allergology
Research on adult invasive bacterial infection surveillance construction
Other
NO
2014 | Year | 10 | Month | 01 | Day |
Published
https://www.ncbi.nlm.nih.gov/pubmed/29983256
IgG concentrations to serotype 19F were increased in all groups in response to the vaccine. Both PCV13 and PPSV23 induced IgG concentrations in patients immunized for the first time. Response rates for the ILD group were comparable with those for the ILD group undergoing corticosteroid therapy. Only idiopathic pulmonary fibrosis patients undergoing immunosuppressive therapy had a significantly lower response.
Completed
2014 | Year | 09 | Month | 18 | Day |
2014 | Year | 10 | Month | 01 | Day |
2016 | Year | 09 | Month | 30 | Day |
2016 | Year | 09 | Month | 30 | Day |
2016 | Year | 12 | Month | 31 | Day |
2017 | Year | 12 | Month | 31 | Day |
It is a prospective observational study that sera were collected before vaccination, 4 weeks and 12 months later, to examine the antibody titers.
2014 | Year | 09 | Month | 22 | Day |
2018 | Year | 09 | Month | 25 | Day |
Value
https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000017687
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