Unique ID issued by UMIN | UMIN000014741 |
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Receipt number | R000017135 |
Scientific Title | Detection of chemotherapy induced cardiac TOXicity in breast cancer study |
Date of disclosure of the study information | 2014/08/01 |
Last modified on | 2018/09/02 14:21:26 |
Detection of chemotherapy induced cardiac TOXicity in breast cancer study
DETOX Study
Detection of chemotherapy induced cardiac TOXicity in breast cancer study
DETOX Study
Japan |
Patients with breast cancer undergoing anthracycline chemotherapy
Medicine in general | Cardiology | Breast surgery |
Malignancy
NO
To investigate the incidence and predictors of cardiotoxicity with anthracycline chemotherapy in patients with breast cancer and to evaluate whether cardiac biomarkers predict early myocardial damage or onset of heart failure in these patients.
Safety
Exploratory
Explanatory
Not applicable
Incidence of cardiotoxicity defined as a reduction of left ventricular ejection fraction >=5% to <55% with symptoms of heart failure or an asymptomatic reduction of left ventricular ejection fraction >=10% to <55%.
cardiac biomarkers
echocardiographic parameters
symptoms and signs of heart failure
heart failure admission
usage of cardioprotective drugs
Observational
Not applicable |
Not applicable |
Male and Female
Patients with breast cancer undergoing anthracycline chemotherapy in the Kyoto University Hospital from 2014 to 2015.
Patients who declined to participate in the study.
100
1st name | |
Middle name | |
Last name | Takeshi Kimura |
Kyoto University Hospital
Department of Cardiovascular Medicine
54, Kawahara-cho, Shogoin, Sakyo-ku, Kyoto, Kyoto, Japan.
0757514255
taketaka@kuhp.kyoto-u.ac.jp
1st name | |
Middle name | |
Last name | Kenji Nakatsuma |
Kyoto University Hospital
Department of Cardiovascular Medicine
54, Kawahara-cho, Shogoin, Sakyo-ku, Kyoto, Kyoto, Japan.
0757514255
kj1004@kuhp.kyoto-u.ac.jp
Department of Cardiovascular Medicine, Kyoto University Hospital
Abbott Japan
Profit organization
Kyoto University Cancer Center, Kyoto University Hospital
NO
2014 | Year | 08 | Month | 01 | Day |
Unpublished
Completed
2014 | Year | 07 | Month | 24 | Day |
2014 | Year | 08 | Month | 18 | Day |
2017 | Year | 02 | Month | 14 | Day |
2017 | Year | 05 | Month | 01 | Day |
2018 | Year | 04 | Month | 01 | Day |
2018 | Year | 08 | Month | 01 | Day |
Patient enrollment: July 2014-June 2016
2014 | Year | 08 | Month | 01 | Day |
2018 | Year | 09 | Month | 02 | Day |
Value
https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000017135
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