Unique ID issued by UMIN | UMIN000014048 |
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Receipt number | R000016355 |
Scientific Title | Visualization and Qualification of Abnormal Semantic Representation in Schizophrenia |
Date of disclosure of the study information | 2014/05/23 |
Last modified on | 2022/11/28 10:04:30 |
Visualization and Qualification of Abnormal Semantic Representation in Schizophrenia
Visualization and Qualification of Abnormal Semantic Representation in Schizophrenia
Visualization and Qualification of Abnormal Semantic Representation in Schizophrenia
Visualization and Qualification of Abnormal Semantic Representation in Schizophrenia
Japan |
schizophrenia
Psychiatry |
Others
NO
The aim of this study is to visualize and quantify semantic representation in the schizophrenia brain using the "semantic representation map", which enables us to do how various words or ideas appear to associate with in the brain. We also aim to investigate the neural basis of thought disorder and its relationship with therapeutic effect in schizophrenia.
Efficacy
Exploratory
Others
Not applicable
The primary outcome is to evaluate abnormal visual information processing in schizophrenia by comparing cortical activation and semantic representation maps between groups, and investigate the symptomatologic significance using psychological measures.
The key secondary outcome is to examine the treatment effects by comparing how much the treatments affect above-mentioned parameters.
Interventional
Parallel
Non-randomized
Open -no one is blinded
No treatment
2
Diagnosis
Device,equipment |
We perform functional MRI scanning for healthy group using various movies or psychological tasks as visual stimuli. We investigate its voxelwise relationships with conceptual thesaurus made from the stimuli.
We perform functional MRI scanning for schizophrenia group using various movies or psychological tasks as visual stimuli. We investigate its voxelwise relationships with conceptual thesaurus made from the stimuli. We evaluate how they change chronologically (about 3-12 months) by clinical therapeutic intervention.
16 | years-old | <= |
60 | years-old | > |
Male and Female
schizophrenia patients with stable symptoms and age-matches healthy controls with no abnormality in central nervous system
a person under sixteen or from sixty years and up, a person with nervous disease or disease which could affect nervous system regeneration, and a person who is not sufficiently able to agree with due to the condition of disease
40
1st name | |
Middle name | |
Last name | TAKAHASHI Hidehiko |
Kyoto University Graduate School of Medicine
Department of Psychiatry
54, Shogoin-Kawahara-cho, Sakyo-ku, Kyoto
075-751-4947
hidehiko@kuhp.kyoto-u.ac.jp
1st name | |
Middle name | |
Last name | SON Shuraku |
Kyoto University Graduate School of Medicine
Department of Psychiatry
54, Shogoin-Kawahara-cho, Sakyo-ku, Kyoto
075-751-4947
a0089374@kuhp.kyoto-u.ac.jp
Kyoto University Graduate School of Medicine
Strategic Research Program for Brain Science
Other
NO
2014 | Year | 05 | Month | 23 | Day |
Unpublished
Completed
2014 | Year | 04 | Month | 09 | Day |
2014 | Year | 06 | Month | 17 | Day |
2014 | Year | 07 | Month | 01 | Day |
2017 | Year | 02 | Month | 13 | Day |
2014 | Year | 05 | Month | 23 | Day |
2022 | Year | 11 | Month | 28 | Day |
Value
https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000016355
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