Unique ID issued by UMIN | UMIN000013929 |
---|---|
Receipt number | R000016242 |
Scientific Title | Clinical evaluation of tau-imaging PET tracer [18F]THK-5351 |
Date of disclosure of the study information | 2014/05/19 |
Last modified on | 2018/05/15 09:32:44 |
Clinical evaluation of tau-imaging PET tracer [18F]THK-5351
Clinical evaluation of PET tracer [18F]THK-5351
Clinical evaluation of tau-imaging PET tracer [18F]THK-5351
Clinical evaluation of PET tracer [18F]THK-5351
Japan |
Alzheimer's disease and healthy volunteer
Neurology | Geriatrics | Psychiatry |
Radiology | Adult |
Others
NO
This study is aimed at evaluating the clinical usefulness of [18F]THK-5351 as a PET tracer for tau imaging, by the comparison with amyloid PET tracer [11C]PiB in the patients with Alzheimer's disease and healthy volunteers.
Safety,Efficacy
Regional [18F]THK-5351 and [11C]PiB retention in the brain, referenced to cerebellar cortex.
Interventional
Single arm
Non-randomized
Open -no one is blinded
Uncontrolled
1
Diagnosis
Medicine |
[18F]THK-5351 and [11C]PiB PET studies will be performed in the patients with Alzheimer's disease and healthy volunteers. Both PET scans will be performed within 3 months interval.
Dynamic PET images of the brain will be acquired for 90 min after intravenous administration of 185 mBq [18F]THK-5351, and for 70 min after intravenous administration of 296 MBq [11C]PiB.
20 | years-old | <= |
Not applicable |
Male and Female
Healthy normal subjects without cognitive impairment and cerebrovascular lesion, and probable Alzheimer's disease patients (NINCDS-ADRDA criteria)
Subjects with neuropsychiatric diseases other than Alzheimer's disease, subjects with severe cardiac abnormalities, and subjects with pacemaker or metal device in the body.
19
1st name | |
Middle name | |
Last name | Nobuyuki Okamura |
Tohoku University School of Medicine
Department of Pharmacology
2-1, Seiryo-machi, Aoba-ku, Sendai, Miyagi, Japan
022-717-8058
nookamura@med.tohoku.ac.jp
1st name | |
Middle name | |
Last name | Nobuyuki Okamura |
Tohoku University School of Medicine
Department of Pharmacology
2-1, Seiryo-machi, Aoba-ku, Sendai, Miyagi, Japan
022-717-8058
nookamura@med.tohoku.ac.jp
Tohoku University School of Medicine
Ministry of Health, Labour and Welfare
Japanese Governmental office
Japan
NO
東北大学サイクロトロンRIセンター、東北大学病院
2014 | Year | 05 | Month | 19 | Day |
Partially published
Completed
2014 | Year | 05 | Month | 12 | Day |
2014 | Year | 06 | Month | 01 | Day |
2014 | Year | 05 | Month | 12 | Day |
2018 | Year | 05 | Month | 15 | Day |
Value
https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000016242
Research Plan | |
---|---|
Registered date | File name |
Research case data specifications | |
---|---|
Registered date | File name |
Research case data | |
---|---|
Registered date | File name |