Unique ID issued by UMIN | UMIN000013323 |
---|---|
Receipt number | R000015547 |
Scientific Title | liver signal profiling and blood marker research for non-alcoholic fatty liver diseases |
Date of disclosure of the study information | 2014/03/04 |
Last modified on | 2020/10/09 09:09:34 |
liver signal profiling and blood marker research for non-alcoholic fatty liver diseases
liver signal profiling and blood marker research for non-alcoholic fatty liver diseases
liver signal profiling and blood marker research for non-alcoholic fatty liver diseases
liver signal profiling and blood marker research for non-alcoholic fatty liver diseases
Japan |
nonalcoholic fatty liver diseases
Hepato-biliary-pancreatic medicine |
Others
YES
To elucidate the factors associated with pathogenesis and development of nonalcoholic steatohepatitis (NASH) by the profiling of liver and blood collected from nonalcoholic steatohepatitis (NAFLD) patients, furthermore to research the early diagnostic procedure of NASH and create a therapeutic medication for NASH.
Others
Diagnosis and treatment
1) Proceeding Genechip analysis, Methylation BeadChip analysis, and comprehensive analysis of miRNA for signal profiling in liver by using liver biopsy samples collected in each trial sites
2) Proceeding Proteomics analysis, metabolomics analysis, and comprehensive analysis of miRNA to research diagnostic markers for NASH by using blood samples collected in each trial sites
Observational
18 | years-old | <= |
85 | years-old | >= |
Male and Female
Patients with suspected NAFLD by interview, blood collection, imaging studies
1) Persons over 20g per day or 140g per week of alcohol intake
2) Patients who are suspicious of viral hepatitis, autoimmune hepatitis, primary biliary cirrhosis, sclerosing cholangitis, hemochromatosis, alpha1-antitrypsin deficiency, Wilson's disease, drug-induced hepatitis
3) Patients who showed clinical evidence of hepatic decompensation such as hepatic encephalopathy, ascites, variceal bleeding, or a serum bilirubin level greater than twofold the normal upper limit
4) Persons judged inappropriate for this study
100
1st name | Yuichiro |
Middle name | |
Last name | Eguchi |
Saga University Hospital
Division of Hepatology
849-8501
5-1-1 Nabeshima, Saga 849-8501, Japan
0952-34-3010
eguchiyu@cc.saga-u.ac.jp
1st name | Yuichiro |
Middle name | |
Last name | Eguchi |
Saga University Hospital
Division of Hepatology
849-8501
5-1-1 Nabeshima, Saga 849-8501, Japan
0952-34-3010
eguchiyu@cc.saga-u.ac.jp
Saga Medical School
Hiroshima University
Yokohama City University Graduate School of Medicine
Takeda Pharmaceutical Company
Saga Uiversity
Self funding
Saga Uiversity
5-1-1 Nabeshima, Saga 849-8501, Japan
0952-34-3010
eguchiyu@cc.saga-u.ac.jp
NO
佐賀大学病院(佐賀県)、広島大学病院(広島県)、横浜市立大学病院(神奈川県)、武田薬品工業株式会社(神奈川県)
2014 | Year | 03 | Month | 04 | Day |
Unpublished
Open public recruiting
2013 | Year | 10 | Month | 01 | Day |
2013 | Year | 10 | Month | 25 | Day |
2014 | Year | 02 | Month | 28 | Day |
2023 | Year | 03 | Month | 31 | Day |
This study is observational study.
Samples are collected from patients with suspected NAFLD by interview, blood collection, imaging studies. In some cases, samples are collected two or more times from the same person.
Analysis is conducted prospectively with the samples collected after the date of registration.
2014 | Year | 03 | Month | 04 | Day |
2020 | Year | 10 | Month | 09 | Day |
Value
https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000015547