Unique ID issued by UMIN | UMIN000012590 |
---|---|
Receipt number | R000014726 |
Scientific Title | The retrospective study of treatment by thrombomodulin for acute exacerbations of idiopathic pulmonary fibrosis, acute respiratory distress sydmrome |
Date of disclosure of the study information | 2014/01/01 |
Last modified on | 2013/12/16 11:41:29 |
The retrospective study of treatment by thrombomodulin for acute exacerbations of idiopathic pulmonary fibrosis, acute respiratory distress sydmrome
The treatment of thrombomodulin for acute respiratory failure
The retrospective study of treatment by thrombomodulin for acute exacerbations of idiopathic pulmonary fibrosis, acute respiratory distress sydmrome
The treatment of thrombomodulin for acute respiratory failure
Japan |
acute exacerbations of idiopathic pulmonary fibrosis, acute respiratory distress syndrome
Pneumology |
Others
NO
the additional administration of rhTM for AE-IPF-patients has any beneficial effects on outocome, inflammatory mediators and activated coagulation.
Safety,Efficacy
Others
Not applicable
The outcomes of patients included the 28-day mortality and in-hospital mortality after beginning treatment with rhTM were compared with those of untreated patients.
We investigated whether or not they showed any improvement in oxygenation (SpO2/FIO2) and intravascular coagulation disturbance (TAT, FDP) in the acute phase.
Single arm
Non-randomized
Open -no one is blinded
Historical
1
Treatment
Medicine |
Thrombomodulin
20 | years-old | <= |
85 | years-old | >= |
Male and Female
The diagnosis of AE-IPF was based on the criteria, which state that all of the following three conditions must be satisfied during the course of IPF with an unexplained worsening of dyspnea within one month: (1) increased dyspnea, (2) new HRCT appearance, (3) greater than 10-mmHg decreases in oxygen partial pressure (PaO2) in the resting arterial blood compared to previous measurements. The typical HRCT appearance of AE-IPF involved ground glass opacity and/or consolidation as a new appearance on honeycombing. The criteria for the diagnosis of ARDS, as set by the Berlin Definition
The AE-IPF-patients were excluded if they had obvious signs of infection, preexisting pulmonary embolisms, left heart failure, pulmonary hypertension due to pulmonary thromboemboli or phlebitis based on the findings of color Doppler ultrasonography or enhanced HRCT.
Patient or family refusal for invasive mechanical ventilation was an exclusionary criterion for endotracheal intubation. Such patients were excluded from this study.
50
1st name | |
Middle name | |
Last name | Koichiro Tatsumi |
Chiba University
Department of Respirology, Graduate School of Medicine
1-8-1 Inohana Chuo-ku Chiba 260-8670 Japan
043-226-2800
tatsumi@faculty.chiba-u.jp
1st name | |
Middle name | |
Last name | Kenji Tsushima |
Chiba University
Department of Respirology, Graduate School of Medicine
1-8-1 Inohana Chuo-ku Chiba 260-8670 Japan
043-226-2800
tsushimakenji@yahoo.co.jp
Chiba University
Department of Respirology, Graduate School of Medicine, Chiba University
Other
ShinonoiGeneral Hospital
First Department of Internal Medicine, Shinshu University School of Medicine
NO
2014 | Year | 01 | Month | 01 | Day |
Partially published
Open public recruiting
2010 | Year | 04 | Month | 01 | Day |
2010 | Year | 04 | Month | 01 | Day |
2013 | Year | 12 | Month | 16 | Day |
2013 | Year | 12 | Month | 16 | Day |
Value
https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000014726