UMIN-CTR Clinical Trial

Fourteen obese patients and the same number of non-obese patients with similar backgrounds to the obese patients were selected from medical records. Doses of dexmedetomidine (DEX) in the first 48 h or until the end of sedation or extubation were calculated for comparison.
There were no significant differences in DEX dose indices between the groups. However, DEX requirements (mcg/h) were significantly increased with TBW (kg) (r = 0.51, P = 0.003), BMI (r = 0.49, P = 0.006) and LBM (kg) (r = 0.42, P = 0.02).

Patients with American Society of Anesthesiologists physical status 1 to 3, aged 18-80 years old, had a body mass index (BMI) >= 30 kg/m2 and received DEX and FEN during mechanical ventilation after elective major surgeries between January 2011 and July 2013, were selected as an obese group. The same number of patients, whose background including age-group and sex were matched to those in the obese group and whose BMI was < 30 kg/m2, were randomly selected as a non-obese group. The exclusion criteria included patients with history of neuropsychiatric disorder, brain surgery, psychotropic drug usage, preoperative disturbance of consciousness, or hepatectomy, patients with brain injuries that were later identified, and patients with prolonged intra- or postoperative shock and did not respond to treatment.

(Retrospective analysis)

NA

Total doses of DEX and FEN between the initiation and the time point when sedation was terminated or the patients trachea was extubated within 48 h, or during the first 48 h when sedation was prolonged further, were extracted from medical records.