Unique ID issued by UMIN | UMIN000012534 |
---|---|
Receipt number | R000014592 |
Scientific Title | Clinical application of corneal endothelial regenerative medicine by means of cultured human corneal endothelial cell transplantation |
Date of disclosure of the study information | 2013/12/09 |
Last modified on | 2024/10/15 09:31:05 |
Clinical application of corneal endothelial regenerative medicine by means of cultured human corneal endothelial cell transplantation
Clinical application of corneal endothelial regenerative medicine by means of cultured human corneal endothelial cell transplantation
Clinical application of corneal endothelial regenerative medicine by means of cultured human corneal endothelial cell transplantation
Clinical application of corneal endothelial regenerative medicine by means of cultured human corneal endothelial cell transplantation
Japan |
Bullous Keratopathy
Ophthalmology |
Others
NO
To verify the efficacy of human cultured corneal endothelial cell transplantation, and the safety of cultured corneal endothelial transplantation will be verified.
Safety,Efficacy
Corneal Endothelial Cell Density > 500 cells/mm2 (24W)
Corneal Thickness < 630 micro meter and no corneal epithelial edema
Improvement of visual acuity (24W)
Improvement of VFQ-25 (24W)
Interventional
Single arm
Non-randomized
Open -no one is blinded
Uncontrolled
1
Treatment
Medicine |
ROCK inhibitor
caltivated human corneal endothelial cell
20 | years-old | <= |
90 | years-old | > |
Male and Female
BSCVA under 0.5
Corneal thickness over 630 micro meter with corneal epithelial edema
corneal endothelial cell density unmesurable or under 500cells per mm2
corneal infection
pregnant
bleeding tendency
mental disability
uncontrolable glaucoma
uncontrolable diabetes
autoimmune disease
cancer patient
heart disease
45
1st name | Shigeru |
Middle name | |
Last name | Kinoshita |
Kyoto Prefectural University of Medicine
Frontier Medical Science and Technology for Ophthalmology
6028566
465 Kajii-cho, kamigyo-ku, Kyoto-shi,Kyoto
075-251-5578
shigeruk@koto.kpu-m.ac.jp
1st name | Morio |
Middle name | |
Last name | Ueno |
Kyoto Prefectural University of Medicine
Ophthalmology
6028566
465 Kajii-cho, kamigyo-ku, Kyoto-shi,Kyoto
075-251-5578
mueno@koto.kpu-m.ac.jp
Kyoto Prefectural University of Medicine
MHLW
Japanese Governmental office
KPUM IRB
465 Kajii-cho kamigyo-ku
+81752515337
rinri@koto.kpu-m.ac.jp
NO
2013 | Year | 12 | Month | 09 | Day |
Unpublished
https://www.nejm.org/doi/10.1056/NEJMoa1712770?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_d
Open public recruiting
2012 | Year | 12 | Month | 19 | Day |
2012 | Year | 11 | Month | 01 | Day |
2013 | Year | 12 | Month | 09 | Day |
2025 | Year | 05 | Month | 31 | Day |
2013 | Year | 12 | Month | 09 | Day |
2024 | Year | 10 | Month | 15 | Day |
Value
https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000014592