Unique ID issued by UMIN | UMIN000011650 |
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Receipt number | R000013621 |
Scientific Title | Low dose atrial natriuretic peptide provides effective renal protection from acute kidney injury after aortic arch surgery: a randomised controlled trial |
Date of disclosure of the study information | 2013/09/04 |
Last modified on | 2013/09/04 13:37:38 |
Low dose atrial natriuretic peptide provides effective renal protection from acute kidney injury after aortic arch surgery: a randomised controlled trial
Kawasaki ANP trial
Low dose atrial natriuretic peptide provides effective renal protection from acute kidney injury after aortic arch surgery: a randomised controlled trial
Kawasaki ANP trial
Japan |
acute kidney injury
Cardiology | Nephrology | Vascular surgery |
Anesthesiology | Cardiovascular surgery | Intensive care medicine |
Others
NO
To evaluate whether an intravenous atrial natriuretic peptide infusion prevents acute kidney injury in patients undergoing aortic arch surgery requiring deep hypothermic circulatory arrest.
Safety,Efficacy
The primary end point was the incidence of AKI within 48 hours after surgery.
Interventional
Parallel
Randomized
Double blind -all involved are blinded
Placebo
2
Prevention
Medicine |
Patients are randomly assigned to receive a fixed dose of atrial natriuretic peptide (0.0125microgram kg-1 min-1) or placebo. The infusion is started after induction of anesthesia and continued for 24 hours postoperatively.
equivalent volume of 5% glucose (placebo)
20 | years-old | <= |
Not applicable |
Male and Female
a) elective aortic arch surgery;
b) preoperative serum creatinine under 1.3 mg/dL
1) an additional procedure was planned or undertaken
2) the arterial or venous cannulation sites were modified
3) the patient required an ANP infusion to treat perioperative acute heart failure
4) the patient age under 20 years
5) the patient had a history of adverse reaction to atrial natriuretic peptide
6) mean arterial blood pressure could not be maintained above 50 mmHg despite the administration of a positive inotrope or vasopressor after weaning from cardiopulmonary bypass.
43
1st name | |
Middle name | |
Last name | Yosuke Mori |
Kawasaki Saiwai Hospital
Department of Anesthesia
31-27 Omiya, Saiwai, Kawasaki, Kanagawa, Japan
044-544-4611
yosuke@mori.name
1st name | |
Middle name | |
Last name | Yosuke Mori |
Kawasaki Saiwai Hospital
Department of Anesthesia
31-27 Omiya, Saiwai, Kawasaki, Kanagawa, Japan
044-544-4611
yosuke@mori.name
Kawasaki Saiwai Hospital
Kawasaki Saiwai Hospital
Non profit foundation
NO
2013 | Year | 09 | Month | 04 | Day |
Unpublished
Completed
2011 | Year | 02 | Month | 04 | Day |
2011 | Year | 02 | Month | 05 | Day |
2013 | Year | 09 | Month | 04 | Day |
2013 | Year | 09 | Month | 04 | Day |
Value
https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000013621
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