Unique ID issued by UMIN | UMIN000009869 |
---|---|
Receipt number | R000011562 |
Scientific Title | Usefulness of dexmedetomidine for prevention of emergent agitation in infants undergoing palatoplasty |
Date of disclosure of the study information | 2013/01/25 |
Last modified on | 2013/01/25 10:51:55 |
Usefulness of dexmedetomidine for prevention of emergent agitation in infants undergoing palatoplasty
Usefulness of dexmedetomidine
Usefulness of dexmedetomidine for prevention of emergent agitation in infants undergoing palatoplasty
Usefulness of dexmedetomidine
Japan |
cleft palate
Oral surgery |
Others
NO
The incidence of emergent agitation (EA) after sevoflurane (Sev) anesthesia is high in infants. Although opioids are often used for pain control and to reduce the incidence and severity of EA, anesthesiologists must pay attention to the risk of postoperative resiratory complications. This is particularly important in infants undergoing palatoplasty because edema at the operative site leads to obstructive symptoms and hypoxemia. Dexmedetomidine (Dex) has sedative and analgesic properties without respiratory depression. Some studies have shown the effectiveness of Dex in postoperative recovery, however, the usefulness of Dex in infants undergoing palatoplasty has not yet been well established. We designed a prospective, double-blind, randomized control study to determine the effects of Dex on postoperative recovery in infants undergoing palatoplasty.
Efficacy
To determine the effects of Dex on postoperative recovery in infants undergoing palatoplasty.
Interventional
Parallel
Randomized
Double blind -all involved are blinded
No treatment
2
Treatment
Medicine |
In the Dex group, Dex was given from about 10 minutes before the end of the operation.
In the saline group, the equivalent amount of saline was administered in the same manner.
10 | months-old | <= |
14 | months-old | >= |
Male and Female
Participants were required to be ASA physical status class1, aged 10 to 14 months years old, weight between 7 and 10 kg, and have a height between 70 and 80 cm.
Exclusion criteria included patient refusal, ASA class2, cardiovascular disease, or allergy.
70
1st name | |
Middle name | |
Last name | Boku Aiji |
Osaka University Graduate School of Dentistry
Department of Dental Anesthesiology
1-8, Yamadaoka, Suita, Japan
06-6879-2972
1st name | |
Middle name | |
Last name |
Osaka University Graduate School of Dentistry
Department of Dental Anesthesiology
si-soumu-syomu@office.osaka-u.ac.j
Osaka University Graduate School of Dentistry
Osaka University Graduate School of Dentistry
Other
NO
2013 | Year | 01 | Month | 25 | Day |
Unpublished
Completed
2011 | Year | 08 | Month | 23 | Day |
2011 | Year | 09 | Month | 01 | Day |
2013 | Year | 01 | Month | 25 | Day |
2013 | Year | 01 | Month | 25 | Day |
Value
https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000011562