UMIN-CTR Clinical Trial
| Unique ID issued by UMIN | UMIN000011009 |
|---|---|
| Receipt number | R000010516 |
| Scientific Title | Identification of proteins involved in the pathogenesis of colorectal tumor progression |
| Date of disclosure of the study information | 2013/06/19 |
| Last modified on | 2013/06/19 19:13:48 |
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Basic information
Public title
Identification of proteins involved in the pathogenesis of colorectal tumor progression
Acronym
Identification of proteins involved in the pathogenesis of colorectal tumor progression
Scientific Title
Identification of proteins involved in the pathogenesis of colorectal tumor progression
Scientific Title:Acronym
Identification of proteins involved in the pathogenesis of colorectal tumor progression
Region
| Japan |
Condition
Condition
Colorectal Tumor
Colorectal Cancer
Classification by specialty
| Gastroenterology |
Classification by malignancy
Malignancy
Genomic information
NO
Objectives
Narrative objectives1
Carcinogenesis has been suggested that autophagy-lysosome endoplasmic reticulum stress, oxidative stress-induced inflammation contributes substantially to disease progression.
We intended that comprehensive functional analysis of each samples reveals distinct loss-of-function mechanisms associated with Carcinogenesis
Basic objectives2
Others
Basic objectives -Others
To assess the function of autophagy in tissue by immunohistochemical staining of colon tissue of ubiquitin and p62.
Trial characteristics_1
Exploratory
Trial characteristics_2
Explanatory
Developmental phase
Not applicable
Assessment
Primary outcomes
Measure auto-lysosome function in the cytoplasm by electron microscopy to examine the changes in the number of autophagy.
Key secondary outcomes
Base
Study type
Observational
Study design
Basic design
Randomization
Randomization unit
Blinding
Control
Stratification
Dynamic allocation
Institution consideration
Blocking
Concealment
Intervention
No. of arms
Purpose of intervention
Type of intervention
Interventions/Control_1
Interventions/Control_2
Interventions/Control_3
Interventions/Control_4
Interventions/Control_5
Interventions/Control_6
Interventions/Control_7
Interventions/Control_8
Interventions/Control_9
Interventions/Control_10
Eligibility
Age-lower limit
| Not applicable |
Age-upper limit
| Not applicable |
Gender
Male and Female
Key inclusion criteria
Colorectal cancer or Adenoma
Key exclusion criteria
The patient who does not agree the study
Target sample size
30
Research contact person
Name of lead principal investigator
| 1st name | |
| Middle name | |
| Last name | Naoto Sakamoto |
Organization
juntendo University
Division name
the division of gastroenterology
Zip code
Address
2-1-1 Hongo Bunkyoku Tokyo
TEL
Public contact
Name of contact person
| 1st name | |
| Middle name | |
| Last name |
Organization
Juntendo University
Division name
the division of gastroenterology
Zip code
Address
TEL
Homepage URL
Sponsor or person
Institute
Juntendo University
Institute
Department
Personal name
Funding Source
Organization
none
Organization
Division
Category of Funding Organization
Self funding
Nationality of Funding Organization
Other related organizations
Co-sponsor
Name of secondary funder(s)
IRB Contact (For public release)
Organization
Address
Tel
Secondary IDs
Secondary IDs
NO
Study ID_1
Org. issuing International ID_1
Study ID_2
Org. issuing International ID_2
IND to MHLW
Institutions
Institutions
Other administrative information
Date of disclosure of the study information
| 2013 | Year | 06 | Month | 19 | Day |
Related information
URL releasing protocol
Publication of results
Unpublished
Result
URL related to results and publications
Number of participants that the trial has enrolled
Results
Results date posted
Results Delayed
Results Delay Reason
Date of the first journal publication of results
Baseline Characteristics
Participant flow
Adverse events
Outcome measures
Plan to share IPD
IPD sharing Plan description
Progress
Recruitment status
Open public recruiting
Date of protocol fixation
| 2012 | Year | 07 | Month | 01 | Day |
Date of IRB
Anticipated trial start date
| 2012 | Year | 07 | Month | 01 | Day |
Last follow-up date
Date of closure to data entry
Date trial data considered complete
Date analysis concluded
Other
Other related information
We follow up the patient condition after biopsy
Management information
Registered date
| 2013 | Year | 06 | Month | 19 | Day |
Last modified on
| 2013 | Year | 06 | Month | 19 | Day |
Link to view the page
Value
https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000010516
