Unique ID issued by UMIN | UMIN000007575 |
---|---|
Receipt number | R000008935 |
Scientific Title | Positron emission tomography using a newly-developed PET probe: [18F] Fluoroacetate (FACE) - human volunteer study - |
Date of disclosure of the study information | 2012/04/01 |
Last modified on | 2019/03/27 11:54:51 |
Positron emission tomography using a newly-developed PET probe: [18F] Fluoroacetate (FACE) - human volunteer study -
FACE volunteer study
Positron emission tomography using a newly-developed PET probe: [18F] Fluoroacetate (FACE) - human volunteer study -
FACE volunteer study
Japan |
healthy volunteer
Adult |
Others
NO
With the use of new PET tracer, [18F] Fluoroacetate (FACE), we would like to establish a new molecular imaging PET study for the quantitative evaluation of TCA cycle/ membrane metabolism of cancers, heart diseases, and brain. This study is the first trial with healthy volunteers.
Pharmacokinetics
Confirmatory
Pragmatic
Phase I
Dynamic data acquisition (0 min after the intravenous injection up to 3hr after injection) using PET machine.
Radiation exposure will be also evaluated using dynamic data.
Interventional
Single arm
Non-randomized
Open -no one is blinded
Uncontrolled
1
Diagnosis
Other |
Injection dose 5.0MBq per kg, maximum dose 370MBq.
Dynamic and static data acquisition up to 1.5 hours.
Venous blood sampling up to 32mL.
20 | years-old | <= |
80 | years-old | > |
Male and Female
healthy volunteer
a person with a disease (diseases)
20
1st name | |
Middle name | |
Last name | Tatsuya Higashi |
Shiga Medical Center Research Institute
Division of Imaging Research
5-4-40 Moriyama, Moriyama-City, Shiga
077-582-6034
pet-ml@shigamed.jp
1st name | |
Middle name | |
Last name | Tatsuya Higashi |
Shiga Medical Center Research Institute
Division of Imaging Research
5-4-40 Moriyama, Moriyama-City, Shiga
077-582-6034
http://www.shigamed.jp/
pet-ml@shigamed.jp
Shiga Medical Center Research Institute
Shiga Medical Center Research Institute
Self funding
Japan
NO
滋賀県立総合病院研究所
2012 | Year | 04 | Month | 01 | Day |
http://www.shigamed.jp/
Published
http://www.shigamed.jp/
4
Annals of Nuclear Medicine
Ann Nucl Med (2014) 28:371-380
Assessment of [18F]-fluoroacetate PET/CT as a tumor-imaging
modality: preclinical study in healthy volunteers and clinical
evaluation in patients with liver tumor
2019 | Year | 03 | Month | 27 | Day |
2014 | Year | 03 | Month | 06 | Day |
Twenty four normal healthy volunteers
(male: 15, female: 9)
Recruit for volunteers was performed by web homepage of our institute. After the obtain of informed consent, volunteers participate our study.
none
We performed whole-body static
PET/CT scan using 18F-FACE (n = 34) and 18F-FDG (n = 5 for volunteers, n = 8 for patients) on each day,
respectively.
Completed
2012 | Year | 03 | Month | 22 | Day |
2012 | Year | 04 | Month | 01 | Day |
2013 | Year | 03 | Month | 01 | Day |
2013 | Year | 03 | Month | 01 | Day |
2013 | Year | 03 | Month | 01 | Day |
2013 | Year | 03 | Month | 01 | Day |
Ann Nucl Med. 2014 May;28(4):371-80. doi: 10.1007/s12149-014-0823-z. Epub 2014 Mar 6.
2012 | Year | 03 | Month | 26 | Day |
2019 | Year | 03 | Month | 27 | Day |
Value
https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000008935