Unique ID issued by UMIN | UMIN000007460 |
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Receipt number | R000008797 |
Scientific Title | Effect of genetic polymorphism of glutahione S-transferases for the pharmacokinetics and adverse effects of oxaliplatin in patients with colorectal cancer |
Date of disclosure of the study information | 2012/03/06 |
Last modified on | 2015/09/29 19:50:12 |
Effect of genetic polymorphism of glutahione S-transferases for the pharmacokinetics and adverse effects of oxaliplatin in patients with colorectal cancer
Effect of genetic polymorphism of glutahione S-transferases for the pharmacokinetics and adverse effects of oxaliplatin in patients with colorectal cancer
Effect of genetic polymorphism of glutahione S-transferases for the pharmacokinetics and adverse effects of oxaliplatin in patients with colorectal cancer
Effect of genetic polymorphism of glutahione S-transferases for the pharmacokinetics and adverse effects of oxaliplatin in patients with colorectal cancer
Japan |
colorectal cancer
Hematology and clinical oncology |
Malignancy
YES
We investigate influence of genetic polymorphism of glutathione S-transferase (GST) on the pharmacokinetics(PK) parameter and adverse effects of oxaliplatin (L-OHP) in patients with colorectal cancer.
Pharmacokinetics
genetic polymorphism of GST and PK parameter of L-OHP
Interventional
Single arm
Non-randomized
Open -no one is blinded
Uncontrolled
1
Treatment
Medicine |
Duration of study:2 years
Dose of oxalipatin
Times of blood sampling:11 times
20 | years-old | <= |
75 | years-old | > |
Male and Female
1.patients with colorectal cancer who recieve mFOLFOX6+bevacizumab or mFOLFOX6
2.Performance Status:0~1
1.patients with severe hepatotoxicity or nephrotoxicity
2.patients with neuropathy
20
1st name | |
Middle name | |
Last name | Yuhki Sato |
Oita University Hospital
Pharmacy
1-1, Idaigaoka, Hasama-machi, Yuhu-shi, Oita
1st name | |
Middle name | |
Last name |
Oita University Hospital
Oita University Hospital
syuhki@oita-u.ac.jp
Oita University Hospita
Oita University Hospital
Other
NO
2012 | Year | 03 | Month | 06 | Day |
Unpublished
Completed
2010 | Year | 09 | Month | 30 | Day |
2010 | Year | 10 | Month | 01 | Day |
2012 | Year | 03 | Month | 06 | Day |
2015 | Year | 09 | Month | 29 | Day |
Value
https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000008797
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