Unique ID issued by UMIN | UMIN000005644 |
---|---|
Receipt number | R000006668 |
Scientific Title | Evaluation of cerebral blood flow before and after acupuncture stimulation using arterial spin-labeled MRI for migraine -uncontrolled, open label study- |
Date of disclosure of the study information | 2011/05/26 |
Last modified on | 2020/11/09 17:35:04 |
Evaluation of cerebral blood flow before and after acupuncture stimulation using arterial spin-labeled MRI for migraine
-uncontrolled, open label study-
Japan Evaluation of cerebral blood flow before and after acupuncture stimulation using arterial spin-labeled MRI for migraine
JASCA study
Evaluation of cerebral blood flow before and after acupuncture stimulation using arterial spin-labeled MRI for migraine
-uncontrolled, open label study-
Japan Evaluation of cerebral blood flow before and after acupuncture stimulation using arterial spin-labeled MRI for migraine
JASCA study
Japan |
migaraine
Neurology |
Others
NO
In the update report of Cochrane review analyzing it has not yet been verified whether acupuncture is more useful than fake acupuncture (placebo), but in comparison with the efficacy-established preventive drug therapy, it was concluded that acupuncture is equivalent to or slightly more effective than the preventive drug therapy and induces less adverse events. We investigated the onset mechanism of tension-type headache and the action mechanism of acupuncture using plethysmography, EMG, thermography and open loop video pupillography. As a result, it was found that the hypertension of the posterior cervical, suprascapular and interscapular muscles play more important roles than the hypertension of the head muscles in the onset mechanism of headache, and acupuncture contributes to alleviation of headache by relaxing the hypertension of these muscles and normalizing the circulatory dynamics. It was further clarified that such analgesic mechanism has influences not only on the local reaction (axonal reflex) but also on the high-level central nervous system (Edinger-Westphal Nucleus / periaqueductal gray matter) and the autonomic nerve system is playing important roles.
Then, in this study, for the purpose of clarifying the mechanism of acupuncture against migraine, we will investigate the influences of acupuncture on the cerebral blood flow at the pain-sensitive sites of thalamus, hypothalamus, periaqueductal gray matter, ceruleus nucleus, nucleus raphe magnus, etc., which are considered to be the migraine-inducing organs, by determining the cerebral blood flow changes using ASL as an index
Safety,Efficacy
Confirmatory
Explanatory
Not applicable
cerebral blood flow
Headache diary
Interventional
Single arm
Non-randomized
Open -no one is blinded
Uncontrolled
1
Treatment
Maneuver |
acupuncture
18 | years-old | <= |
65 | years-old | >= |
Male and Female
Migraine headache of the diplomatic relations verge headache classification second edition
The subjects have history of cerebrovascular disorder
10
1st name | Satoru |
Middle name | |
Last name | Yamaguchi |
Saitama Medical University
The Center for Oriental and Integrated Medicine,Saitama Medical University, Saitama, Japan.
350-0495
38,Morohongo,Moroyamamachi,Iruma-gun,Saitama
+81-(0)49-276-1274
sayama@saitama-med.ac.jp
1st name | Satoru |
Middle name | |
Last name | Yamaguchi |
Saitama Medical University
The Center for Oriental and Integrated Medicine,Saitama Medical University, Saitama, Japan.
350-0495
38,Morohongo,Moroyamamachi,Iruma-gun,Saitama
+81-(0)49-276-1274
http://www.saitama-med.ac.jp/hospital/division_info/26.html
sayama@saitama-med.ac.jp
Saitama Medical University
Saitama Medical University
Other
Japan
IRBl ,Saitama Medical University, Saitama, Japan.
38,Morohongo,Moroyamamachi,Iruma-gun,Saitama
049-276-1354
hirb@saitama-med.ac.jp
NO
2011 | Year | 05 | Month | 26 | Day |
https://touyouigakuka.wixsite.com/touyou-2/blank-7
Unpublished
20
The target cases are 11 patients with migraine (4 males and 7 females) and 11 healthy adults (6 males and 4 females).
2019 | Year | 06 | Month | 10 | Day |
Delay expected |
Because the analysis is delayed
migraine
Open call for participants
Diagnosis by a specialist
Inform outlet
Cerebral blood flow evaluation
none
Cerebral blood flow
Completed
2010 | Year | 09 | Month | 01 | Day |
2011 | Year | 07 | Month | 23 | Day |
2011 | Year | 07 | Month | 22 | Day |
2013 | Year | 03 | Month | 31 | Day |
2014 | Year | 03 | Month | 31 | Day |
2014 | Year | 03 | Month | 31 | Day |
2014 | Year | 03 | Month | 31 | Day |
2011 | Year | 05 | Month | 25 | Day |
2020 | Year | 11 | Month | 09 | Day |
Value
https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000006668