Unique ID issued by UMIN | UMIN000001709 |
---|---|
Receipt number | R000002063 |
Scientific Title | Multikinase Inhibitor (Tyrosine and Serine/Threonine Kinase Inhibitor) for the Treatment of Severe Pulmonary Arterial Hypertension |
Date of disclosure of the study information | 2009/02/16 |
Last modified on | 2009/02/14 00:19:52 |
Multikinase Inhibitor (Tyrosine and Serine/Threonine Kinase Inhibitor) for the Treatment of Severe Pulmonary Arterial Hypertension
Multikinase Inhibitor for Pulmonary Arterial Hypertension
Multikinase Inhibitor (Tyrosine and Serine/Threonine Kinase Inhibitor) for the Treatment of Severe Pulmonary Arterial Hypertension
Multikinase Inhibitor for Pulmonary Arterial Hypertension
Japan |
pulmonary arterial hypertension
Cardiology |
Others
NO
To evaluate the effects of multikinase inhibitor (sorafenib) for the treatment of severe pulmonary arterial hypertension, which is refractory for conventional therapies
Safety,Efficacy
subjective symptom (WHO functional classification), 6 minutes walk test, echocardiography, right heart catheterization, serum BNP level
Interventional
Single arm
Non-randomized
Open -no one is blinded
Uncontrolled
1
Treatment
Medicine |
administration of sorafenib, which is the multikinase inhibitor (tyrosine and serine/threonine kinase inhibitor)
20 | years-old | <= |
Not applicable |
Male and Female
patients with severe pulmonary arterial hypertension who are refractory for conventional therapies such as PGIS, Ca-blocker, bosentan, and sildenafil
patients who can not express subjective symptoms, can not be evaluated through objective improvement, have the past history of thromboembolism, have the systemic hypertensive disease, have critical liver cirrhosis, are during pregnancy or during lactation, have critical left heart disease, or are receiving hemodialysis.
10
1st name | |
Middle name | |
Last name | Toru Satoh |
School of Medicine, Keio University
Medical Education Center
35 Shinanomachi, Shinjuku-ku, Tokyo
1st name | |
Middle name | |
Last name |
School of Medicine, Keio University
Medical Education Center
m.kataoka@cpnet.med.keio.ac.jp
Medical Education Center, School of Medicine, Keio University
none
Self funding
NO
2009 | Year | 02 | Month | 16 | Day |
Unpublished
Preinitiation
2009 | Year | 01 | Month | 06 | Day |
2009 | Year | 02 | Month | 01 | Day |
2010 | Year | 02 | Month | 01 | Day |
2009 | Year | 02 | Month | 14 | Day |
2009 | Year | 02 | Month | 14 | Day |
Value
https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000002063