Unique ID issued by UMIN | UMIN000001718 |
---|---|
Receipt number | R000002056 |
Scientific Title | Clinical study of the correlation between cholesterol absorption and coronary risk factors or arteriosclerotic diseases, and of the clinical significance of the controlling cholesterol absorption. |
Date of disclosure of the study information | 2009/02/23 |
Last modified on | 2011/08/16 17:20:56 |
Clinical study of the correlation between cholesterol absorption and coronary risk factors or arteriosclerotic diseases, and of the clinical significance of the controlling cholesterol absorption.
Clinical study of the inhibition of cholesterol absorption.
Clinical study of the correlation between cholesterol absorption and coronary risk factors or arteriosclerotic diseases, and of the clinical significance of the controlling cholesterol absorption.
Clinical study of the inhibition of cholesterol absorption.
Japan |
Hypercholesterolemia
Endocrinology and Metabolism |
Others
NO
We investigate the association between the balance of cholesterol synthesis/absorption and coronary risk factors or arteriosclerotic diseases. We also assess clinical usefulness of Ezetimibe, a small intestine cholesterol transporter inhibitor.
Efficacy
1. Association between the cholesterol asynthesis/absorption markers before Ezetimibe administration and coronary risk factors or arteriosclerotic diseases.
2. Amount or rate of changes in LDL-C after Ezetimibe administration.
3. Correlation between the amount or rate of changes in LDL-C after Ezetimibe administration and the cholesterol synthesis/absorption markers.
Changes of RLP-cholesterol, HDL-C, triglyceride, insulin, plasma glucose, HbA1c, and hs-CRP.
Interventional
Parallel
Non-randomized
Open -no one is blinded
Uncontrolled
2
Treatment
Medicine |
Twelve weeks Ezetimibe administration to the patients with hypercholesterolemia without statins.
Twelve weeks Ezetimibe administration to the patients with hypercholesterolemia taking statins.
20 | years-old | <= |
Not applicable |
Male and Female
Serum LDL-C level is higher than the management targeted value in Japan atherosclerosis society guidelines for prevention of atherosclerotic cardiovascular diseases 2007.
Severe liver or renal dysfunction.
The patient using fibrate or insulin.
Secondary hypercholesterolemia.
Pregnant women.
200
1st name | |
Middle name | |
Last name | Masamitsu Nakazato |
Miyazaki Medical College, University of Miyazaki
Neurology, Respirology, Endocrinology and Metabolism
5200, kihara, Kiyotake, Miyazaki, Japan
0985-85-2965
1st name | |
Middle name | |
Last name | Hiroaki Ueno |
Miyazaki Medical College, University of Miyazaki
Neurology, Respirology, Endocrinology and Metabolism
5200, kihara, Kiyotake, Miyazaki, Japan
0985-85-2965
intron@med.miyazaki-u.ac.jp
Neurology, Respirology, Endocrinology and Metabolism,
Miyazaki Medical College, University of Miyazaki
Ministry of education, culture, sports, science & technology
Japan
NO
2009 | Year | 02 | Month | 23 | Day |
Unpublished
Completed
2008 | Year | 04 | Month | 01 | Day |
2008 | Year | 05 | Month | 01 | Day |
2009 | Year | 09 | Month | 01 | Day |
2011 | Year | 08 | Month | 01 | Day |
2011 | Year | 08 | Month | 01 | Day |
2011 | Year | 08 | Month | 01 | Day |
2009 | Year | 02 | Month | 19 | Day |
2011 | Year | 08 | Month | 16 | Day |
Value
https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000002056