Unique ID issued by UMIN | UMIN000001492 |
---|---|
Receipt number | R000001738 |
Scientific Title | Pharmacogenetic study on the influence of aldehyde dehydrogenase 2 (ALDH2) gene polymorphism on the vasodilatation induced by organic nitrates |
Date of disclosure of the study information | 2008/11/11 |
Last modified on | 2011/03/30 17:42:45 |
Pharmacogenetic study on the influence of aldehyde dehydrogenase 2 (ALDH2) gene polymorphism on the vasodilatation induced by organic nitrates
The influence of ALDH2 gene polymorphism on the effect of organic nitrates
Pharmacogenetic study on the influence of aldehyde dehydrogenase 2 (ALDH2) gene polymorphism on the vasodilatation induced by organic nitrates
The influence of ALDH2 gene polymorphism on the effect of organic nitrates
Japan |
angina pectoris
Cardiology |
Others
YES
By clinical trials in healthy volunteers, we will determine the relation between genetic polymorphism of the type 2 aldehyde dehydrogenase and the vasodilator action of nitroglycerine and isosorbide dinitrate to personalize the treatment with organic nitrates.
Pharmacodynamics
Confirmatory
Explanatory
Not applicable
Ratio of maximal increase in brachial artery diameter
Time to attain maximal and 90% maximal dilatation of brachial artery
Pulse rate, blood pressure, and their post/pre-administration ratios
Interventional
Cross-over
Randomized
Individual
Open -no one is blinded
Active
YES
NO
Institution is considered as a block.
NO
Numbered container method
2
Prevention
Medicine |
nitroglycerin
isosorbide dinitrate
20 | years-old | <= |
39 | years-old | > |
Male and Female
Older than 20 and younger than 39
Healthy volunteers
Persons whose ALDH2 gene polymorphism is known
History of cardiovascular diseases
Serious liver damages
Serious renal damages
Pregnant women
History of adverse reaction to organic nitrates
Persons using sildenafil, vardenafil, or tadalafil
Systolic blood pressure less than 90 mmHg
Body weight less than 40 kg or more than 90 kg
Persons considered to be unsuitable to the study
72
1st name | |
Middle name | |
Last name | Toshiyuki Sasaguri |
Faculty of Medical Sciences, Kyushu University
Department of Clinical Pharmacology
3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan
092-642-6080
1st name | |
Middle name | |
Last name | Toshiyuki Sasaguri |
Faculty of Medical Sciences, Kyushu University
Department of Clinical Pharmacology
3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan
092-642-6080
sasaguri@med.kyushu-u.ac.jp
Department of Clinical Pharmacology, Faculty of Medical Sciences, Kyushu University
Ministry of Education, Culture, Sports, Science and Technology
Japan
NO
九州大学病院(福岡県) Kyushu University Hospital, Fukuoka, Japan
2008 | Year | 11 | Month | 11 | Day |
Unpublished
Completed
2008 | Year | 09 | Month | 12 | Day |
2008 | Year | 12 | Month | 01 | Day |
2011 | Year | 03 | Month | 01 | Day |
2011 | Year | 03 | Month | 01 | Day |
2011 | Year | 03 | Month | 01 | Day |
2012 | Year | 03 | Month | 01 | Day |
2008 | Year | 11 | Month | 10 | Day |
2011 | Year | 03 | Month | 30 | Day |
Value
https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000001738