UMIN試験ID | UMIN000048997 |
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受付番号 | R000055817 |
科学的試験名 | Effect of adjuvant chemotherapy on localized dedifferentiated low-grade osteosarcoma: a systematic review |
一般公開日(本登録希望日) | 2022/09/22 |
最終更新日 | 2022/09/22 13:22:50 |
日本語
Effect of adjuvant chemotherapy on localized dedifferentiated low-grade osteosarcoma: a systematic review
英語
Effect of adjuvant chemotherapy on localized dedifferentiated low-grade osteosarcoma: a systematic review
日本語
Effect of adjuvant chemotherapy on localized dedifferentiated low-grade osteosarcoma: a systematic review
英語
Effect of adjuvant chemotherapy on localized dedifferentiated low-grade osteosarcoma: a systematic review
日本語
Effect of adjuvant chemotherapy on localized dedifferentiated low-grade osteosarcoma: a systematic review
英語
Effect of adjuvant chemotherapy on localized dedifferentiated low-grade osteosarcoma: a systematic review
日本語
Effect of adjuvant chemotherapy on localized dedifferentiated low-grade osteosarcoma: a systematic review
英語
Effect of adjuvant chemotherapy on localized dedifferentiated low-grade osteosarcoma: a systematic review
日本/Japan | 欧州/Europe |
日本語
dedifferentiated low-grade osteosarcoma(DLOS)
英語
dedifferentiated low-grade osteosarcoma(DLOS)
血液・腫瘍内科学/Hematology and clinical oncology | 整形外科学/Orthopedics |
悪性腫瘍/Malignancy
いいえ/NO
日本語
To investigate the effect of (neo-)adjuvant chemotherapy for localized DLOS, we performed a systematic review of studies comparing mortality and event rates, including local recurrence and distant metastasis, among patients who underwent wide resection or wide resection and (neo-)adjuvant chemotherapy for localized DLOS without distant metastasis at diagnosis.
英語
To investigate the effect of (neo-)adjuvant chemotherapy for localized DLOS, we performed a systematic review of studies comparing mortality and event rates, including local recurrence and distant metastasis, among patients who underwent wide resection or wide resection and (neo-)adjuvant chemotherapy for localized DLOS without distant metastasis at diagnosis.
有効性/Efficacy
日本語
英語
日本語
mortality and event rates, including local recurrence and distant metastasis
英語
mortality and event rates, including local recurrence and distant metastasis
日本語
英語
その他・メタアナリシス等/Others,meta-analysis etc
日本語
英語
日本語
英語
日本語
英語
日本語
英語
日本語
英語
日本語
英語
日本語
英語
日本語
英語
日本語
英語
日本語
英語
1 | 歳/years-old | 以上/<= |
99 | 歳/years-old | 以下/>= |
男女両方/Male and Female
日本語
We included only studies that reported mortality and event rates, such as local recurrence and distant metastasis, after surgery alone or surgery and (neo-)adjuvant chemotherapy for localized DLOS without distant metastasis at diagnosis.
英語
We included only studies that reported mortality and event rates, such as local recurrence and distant metastasis, after surgery alone or surgery and (neo-)adjuvant chemotherapy for localized DLOS without distant metastasis at diagnosis.
日本語
(1) Patients with distant metastasis at the time of DLOS diagnosis were excluded. Studies that did not specify mortality or event rates such as local recurrence or distant metastasis, or did not have a comparison group were also excluded. (2) Patients who underwent surgery alone for primary DLOS and received palliative chemotherapy for distant metastases that developed during the course of the disease were classified into the surgery-only group without adjuvant chemotherapy. (3) Only English- and Japanese-language literature was included, with no restriction on year of publication. Only human subjects were included and animals were excluded.
英語
(1) Patients with distant metastasis at the time of DLOS diagnosis were excluded. Studies that did not specify mortality or event rates such as local recurrence or distant metastasis, or did not have a comparison group were also excluded. (2) Patients who underwent surgery alone for primary DLOS and received palliative chemotherapy for distant metastases that developed during the course of the disease were classified into the surgery-only group without adjuvant chemotherapy. (3) Only English- and Japanese-language literature was included, with no restriction on year of publication. Only human subjects were included and animals were excluded.
日本語
名 | 真治 |
ミドルネーム | |
姓 | 塚本 |
英語
名 | Shinji |
ミドルネーム | |
姓 | Tsukamoto |
日本語
奈良県立医科大学
英語
Nara Medical University
日本語
整形外科
英語
Department of Orthopaedic Surgery
634-8521
日本語
奈良県橿原市四条町840番地
英語
840, Shijo-cho, Kashihara-city Nara 634-8521, Japan
0744223051
shinji104@mail.goo.ne.jp
日本語
名 | 真治 |
ミドルネーム | |
姓 | 塚本 |
英語
名 | Shinji |
ミドルネーム | |
姓 | Tsukamoto |
日本語
奈良県立医科大学
英語
Nara Medical University
日本語
整形外科
英語
Department of Orthopaedic Surgery
634-8521
日本語
奈良県橿原市四条町840番地
英語
840, Shijo-cho, Kashihara-city Nara 634-8521, Japan
0744223051
shinji104@mail.goo.ne.jp
日本語
その他
英語
Nara Medical University
日本語
奈良県立医科大学
日本語
日本語
英語
日本語
その他
英語
Nara Medical University
日本語
奈良県立医科大学
日本語
地方自治体/Local Government
日本語
日本
英語
Nara
日本語
英語
日本語
英語
日本語
奈良県立医科大学
英語
Nara Medical University
日本語
奈良県橿原市四条町840番地
英語
840, Shijo-cho, Kashihara-city Nara 634-8521, Japan
0744223051
shinji104@mail.goo.ne.jp
いいえ/NO
日本語
英語
日本語
英語
2022 | 年 | 09 | 月 | 22 | 日 |
未公表/Unpublished
日本語
英語
日本語
英語
日本語
英語
日本語
英語
日本語
英語
日本語
英語
日本語
英語
日本語
英語
開始前/Preinitiation
2022 | 年 | 09 | 月 | 22 | 日 |
2022 | 年 | 09 | 月 | 22 | 日 |
2022 | 年 | 09 | 月 | 29 | 日 |
日本語
Data collection and presentation
Two authors (ST and TM) independently selected studies and extracted data. In case of any disagreement, agreement was reached between the two or the third author was consulted. The following data were collected using the data collection sheet. (1) Basic data: author, year of publication, journal name, type of study, follow-up period since diagnosis of DLOS, number of patients with localized DLOS (2) Number of patients who underwent surgery and (neo-)adjuvant chemotherapy for localized DLOS and the number of patients who had tumor death, local recurrence or distant metastasis. Number of patients who underwent surgery only for localized DLOS and the number of patients who had tumor death, local recurrence or distant metastasis. (3) Ratio of men to women, age, tumor site, tumor size, and subtype (parosteal or low-grade central osteosarcoma) of the original low-grade osteosarcoma, timing of dedifferentiation (synchronous or metachronous), surgical margins, adjuvant radiotherapy, and percentage of dedifferentiated areas, in the surgery plus (neo-)adjuvant chemotherapy group and the surgery alone group, respectively. (4) chemotherapy regimen, histological evidence of necrosis following preoperative chemotherapy (percentage of necrosis in the entire specimen, including low-grade component).
英語
Data collection and presentation
Two authors (ST and TM) independently selected studies and extracted data. In case of any disagreement, agreement was reached between the two or the third author was consulted. The following data were collected using the data collection sheet. (1) Basic data: author, year of publication, journal name, type of study, follow-up period since diagnosis of DLOS, number of patients with localized DLOS (2) Number of patients who underwent surgery and (neo-)adjuvant chemotherapy for localized DLOS and the number of patients who had tumor death, local recurrence or distant metastasis. Number of patients who underwent surgery only for localized DLOS and the number of patients who had tumor death, local recurrence or distant metastasis. (3) Ratio of men to women, age, tumor site, tumor size, and subtype (parosteal or low-grade central osteosarcoma) of the original low-grade osteosarcoma, timing of dedifferentiation (synchronous or metachronous), surgical margins, adjuvant radiotherapy, and percentage of dedifferentiated areas, in the surgery plus (neo-)adjuvant chemotherapy group and the surgery alone group, respectively. (4) chemotherapy regimen, histological evidence of necrosis following preoperative chemotherapy (percentage of necrosis in the entire specimen, including low-grade component).
2022 | 年 | 09 | 月 | 22 | 日 |
2022 | 年 | 09 | 月 | 22 | 日 |
日本語
https://center6.umin.ac.jp/cgi-open-bin/ctr/ctr_view.cgi?recptno=R000055817
英語
https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000055817
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