UMIN試験ID | UMIN000047442 |
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受付番号 | R000054100 |
科学的試験名 | Effect of adjuvant chemotherapy on extraskeletal osteosarcoma: a systematic review |
一般公開日(本登録希望日) | 2022/04/08 |
最終更新日 | 2022/06/06 10:35:08 |
日本語
Effect of adjuvant chemotherapy on extraskeletal osteosarcoma: a systematic review
英語
Effect of adjuvant chemotherapy on extraskeletal osteosarcoma: a systematic review
日本語
Effect of adjuvant chemotherapy on extraskeletal osteosarcoma: a systematic review
英語
Effect of adjuvant chemotherapy on extraskeletal osteosarcoma: a systematic review
日本語
Effect of adjuvant chemotherapy on extraskeletal osteosarcoma: a systematic review
英語
Effect of adjuvant chemotherapy on extraskeletal osteosarcoma: a systematic review
日本語
Effect of adjuvant chemotherapy on extraskeletal osteosarcoma: a systematic review
英語
Effect of adjuvant chemotherapy on extraskeletal osteosarcoma: a systematic review
日本/Japan | 欧州/Europe |
日本語
extraskeletal osteosarcoma
英語
extraskeletal osteosarcoma
血液・腫瘍内科学/Hematology and clinical oncology | 整形外科学/Orthopedics |
悪性腫瘍/Malignancy
いいえ/NO
日本語
To investigate the effect of (neo-)adjuvant chemotherapy for localized ESOS, we performed a systematic review of studies comparing 5-year disease-free survival rate between patients who received surgery combined with (neo-)adjuvant chemotherapy and patients who received surgery alone.
英語
To investigate the effect of (neo-)adjuvant chemotherapy for localized ESOS, we performed a systematic review of studies comparing 5-year disease-free survival rate between patients who received surgery combined with (neo-)adjuvant chemotherapy and patients who received surgery alone.
有効性/Efficacy
日本語
英語
日本語
5-year disease-free survival rate
英語
5-year disease-free survival rate
日本語
英語
その他・メタアナリシス等/Others,meta-analysis etc
日本語
英語
日本語
英語
日本語
英語
日本語
英語
日本語
英語
日本語
英語
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英語
日本語
英語
日本語
英語
日本語
英語
適用なし/Not applicable |
適用なし/Not applicable |
男女両方/Male and Female
日本語
We included only studies reporting 5-year disease-free survival rate after surgery alone or surgery and (neo-)adjuvant chemotherapy for localized ESOS.
英語
We included only studies reporting 5-year disease-free survival rate after surgery alone or surgery and (neo-)adjuvant chemotherapy for localized ESOS.
日本語
(1) We excluded patients with distant metastases at presentation. We excluded studies that did not specify 5-year disease-free survival rate, did not have a control group, or had fewer than five patients in total. (2) Patients who underwent surgery alone for localized ESOS and received chemotherapy for distant metastases that developed during the course of the disease were classified into the surgery alone group. (3) Only literature in English, Italian, and Japanese was included, and the year of publication was not restricted. Only human studies were included and animal studies were excluded.
英語
(1) We excluded patients with distant metastases at presentation. We excluded studies that did not specify 5-year disease-free survival rate, did not have a control group, or had fewer than five patients in total. (2) Patients who underwent surgery alone for localized ESOS and received chemotherapy for distant metastases that developed during the course of the disease were classified into the surgery alone group. (3) Only literature in English, Italian, and Japanese was included, and the year of publication was not restricted. Only human studies were included and animal studies were excluded.
日本語
名 | 真治 |
ミドルネーム | |
姓 | 塚本 |
英語
名 | Shinji |
ミドルネーム | |
姓 | Tsukamoto |
日本語
奈良県立医科大学
英語
Nara Medical University
日本語
整形外科
英語
Department of Orthopaedic Surgery
634-8521
日本語
奈良県橿原市四条町840番地
英語
840, Shijo-cho, Kashihara-city Nara 634-8521, Japan
0744-22-3051
shinji104@mail.goo.ne.jp
日本語
名 | 真治 |
ミドルネーム | |
姓 | 塚本 |
英語
名 | Shinji |
ミドルネーム | |
姓 | Tsukamoto |
日本語
奈良県立医科大学
英語
Nara Medical University
日本語
整形外科
英語
Department of Orthopaedic Surgery
634-8521
日本語
奈良県橿原市四条町840番地
英語
840, Shijo-cho, Kashihara-city Nara 634-8521, Japan
0744-22-3051
shinji104@mail.goo.ne.jp
日本語
その他
英語
Nara Medical University
日本語
奈良県立医科大学
日本語
日本語
英語
日本語
その他
英語
Nara Medical University
日本語
奈良県立医科大学
日本語
地方自治体/Local Government
日本語
英語
日本語
英語
日本語
英語
日本語
奈良県立医科大学
英語
Nara Medical University
日本語
奈良県橿原市四条町840番地
英語
840, Shijo-cho, Kashihara-city Nara 634-8521, Japan
0744223051
shinji104@mail.goo.ne.jp
いいえ/NO
日本語
英語
日本語
英語
2022 | 年 | 04 | 月 | 08 | 日 |
最終結果が公表されている/Published
761
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日本語
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試験終了/Completed
2022 | 年 | 04 | 月 | 08 | 日 |
2022 | 年 | 04 | 月 | 08 | 日 |
2022 | 年 | 04 | 月 | 08 | 日 |
2022 | 年 | 04 | 月 | 13 | 日 |
2022 | 年 | 06 | 月 | 06 | 日 |
2022 | 年 | 06 | 月 | 06 | 日 |
2022 | 年 | 06 | 月 | 06 | 日 |
日本語
Data collection and presentation
Two authors (ST and LA) independently selected studies and extracted data. In case of disagreement, agreement was reached between the two or the third author was consulted. The following data were collected using the data collection sheet. (1) basic data: author, year of publication, type of study, follow-up period since diagnosis of ESOS, number of patients with localized ESOS. (2) Number of patients who underwent surgery and (neo-) adjuvant chemotherapy for localized ESOS and the number of patients who survived disease-free for 5 years of them. Number of patients who underwent surgery alone for localized ESOS and the number of patients who survived disease-free for 5 years of them. (3) Ratio of male/female patients, age, tumor site, tumor size, surgical margin, adjuvant radiotherapy, and histological grade in the surgery plus (neo-)adjuvant chemotherapy group and the surgery alone group, respectively. (4) Chemotherapy regimen, histologic evidence of necrosis following preoperative chemotherapy.
Data summary, synthesis, and meta-analysis
Data extracted from the collected study data were summarized (Tables 1 and 2). The dataset includes the name of the first author, year of publication, number of patients who underwent surgery and (neo-)adjuvant chemotherapy for localized ESOS and the number of patients who survived 5 years disease-free of them, number of patients who underwent surgery only for localized ESOS and the number of patients who survived 5 years disease-free of them. Random effects models were used to estimate odds ratios to compare 5-year disease-free survival rate between surgery plus (neo-) adjuvant chemotherapy and surgery alone groups. The extent of heterogeneity between studies was evaluated using the inconsistency statistic (I2). All statistical analyses were performed assuming a two-sided test at a 5% level of significance using ProMeta software, version 3 (INTERNOVI di Scarpellini Daniele s.a.s.).
英語
Data collection and presentation
Two authors (ST and LA) independently selected studies and extracted data. In case of disagreement, agreement was reached between the two or the third author was consulted. The following data were collected using the data collection sheet. (1) basic data: author, year of publication, type of study, follow-up period since diagnosis of ESOS, number of patients with localized ESOS. (2) Number of patients who underwent surgery and (neo-) adjuvant chemotherapy for localized ESOS and the number of patients who survived disease-free for 5 years of them. Number of patients who underwent surgery alone for localized ESOS and the number of patients who survived disease-free for 5 years of them. (3) Ratio of male/female patients, age, tumor site, tumor size, surgical margin, adjuvant radiotherapy, and histological grade in the surgery plus (neo-)adjuvant chemotherapy group and the surgery alone group, respectively. (4) Chemotherapy regimen, histologic evidence of necrosis following preoperative chemotherapy.
Data summary, synthesis, and meta-analysis
Data extracted from the collected study data were summarized (Tables 1 and 2). The dataset includes the name of the first author, year of publication, number of patients who underwent surgery and (neo-)adjuvant chemotherapy for localized ESOS and the number of patients who survived 5 years disease-free of them, number of patients who underwent surgery only for localized ESOS and the number of patients who survived 5 years disease-free of them. Random effects models were used to estimate odds ratios to compare 5-year disease-free survival rate between surgery plus (neo-) adjuvant chemotherapy and surgery alone groups. The extent of heterogeneity between studies was evaluated using the inconsistency statistic (I2). All statistical analyses were performed assuming a two-sided test at a 5% level of significance using ProMeta software, version 3 (INTERNOVI di Scarpellini Daniele s.a.s.).
2022 | 年 | 04 | 月 | 08 | 日 |
2022 | 年 | 06 | 月 | 06 | 日 |
日本語
https://center6.umin.ac.jp/cgi-open-bin/ctr/ctr_view.cgi?recptno=R000054100
英語
https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000054100
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